Stimulation design for neuromodulation
The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a burst mode stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder. The burst stimulus comprises a plurality of groups of spike pulses having a maximum inter-spike interval of 100 milliseconds. The burst stimulus is separated by a substantially quiescent period of time between the plurality of groups of spike pulses. This inter-group interval may comprise a minimum of 5 seconds.
1. A method of stimulating nerve tissue of a patient using an implantable pulse generator, the method comprising:
generating, by the implantable pulse generator, a burst stimulus that comprises a repeating pattern of a plurality of groups of pulses, wherein the burst stimulus is substantially quiescent between each adjacent group of pulses, wherein pulses within each group of pulses are repeated at a pulse rate of between approximately 200 Hz and 1000 Hz and groups of pulses within the plurality of groups are repeated at a group rate between approximately 30 Hz and 70 Hz, wherein the burst stimulus is adapted to repetitively cause a group of stimulated neurons to experience a rise above a resting electrical potential to a reference potential, to be maintained at or above the reference potential for a duration of multiple pulses of a respective group of pulses, and to experience spiking from the multiple pulses of the respective group of pulses;
providing the burst stimulus from the implantable pulse generator to a medical lead; and
treating chronic pain in the patient by applying the burst stimulus to stimulate nerve fibers of the spinal cord of the patient via one or several electrodes of the medical lead.
2. The method of claim 1 further comprising:
controlling a number of pukes within a group of pukes of the burst stimulus according a parameter stored in the implantable puke generator.
3. The method of claim 1 further comprising:
controlling a puke amplitude according to a parameter stored in the implantable puke generator.
4. The method of claim 1 further comprising:
controlling a pulse-to-pulse interval according to a parameter stored in the implantable puke generator.
5. The method of claim 1 further comprising:
controlling a group-to-group interval according to a parameter stored in the implantable puke generator.
6. The method of claim 1 further comprising:
controlling a number of groups within the burst stimulus according to a parameter stored in the implantable puke generator.
7. The method of claim 1 further comprising:
generating a hyperpolarizing puke immediately before each group of pukes within the burst stimulus.
8. The method of claim 7 wherein an amplitude of the hyperpolarizing pulse is controllable by a parameter stored in the implantable puke generator.
9. The method of claim 1 wherein one or more electrodes of the medical lead are disposed within the epidural space of the patient between T1 and T12 vertebral levels.
10. A method of stimulating nerve tissue of a patient using an implantable pulse generator, the method comprising:
generating, by the implantable pulse generator, a burst stimulus that comprises a repeating pattern of a plurality of groups of pulses, wherein the burst stimulus is substantially quiescent between each adjacent group of pulses, wherein pulses within each group of pulses are repeated at a pulse rate of between approximately 200 Hz and 1000 Hz and groups of pulses within the plurality of groups are repeated at a group rate between approximately 30 Hz and 70 Hz, wherein groups of pulses within the burst stimulus are adapted to apply temporal summation of stimulation to cause (1) a group of stimulated neurons to experience spiking from multiple pulses of each respective group of pulses and (2) the group of stimulated neurons to exhibit amplitude ramping for multiple spikes induced by each respective group of pulses;
providing the burst stimulus from the implantable pulse generator to a medical lead; and
treating chronic pain in the patient by applying the burst stimulus to stimulate nerve fibers of the spinal cord of the patient via one or several electrodes of the medical lead.
11. The method of claim 10 further comprising:
controlling a number of pulses within a group of pulses of the burst stimulus according a parameter stored in the implantable pulse generator.
12. The method of claim 10 further comprising:
controlling a pulse amplitude according to a parameter stored in the implantable pulse generator.
13. The method of claim 10 further comprising:
controlling a pulse-to-pulse interval according to a parameter stored in the implantable pulse generator.
14. The method of claim 10 further comprising:
controlling a group-to-group interval according to a parameter stored in the implantable pulse generator.
15. The method of claim 10 further comprising:
controlling a number of groups within the burst stimulus according to a parameter stored in the implantable pulse generator.
16. The method of claim 10 further comprising:
generating a hyperpolarizing pulse immediately before each group of pulses within the burst stimulus.
17. The method of claim 16 wherein an amplitude of the hyperpolarizing pulse is controllable by a parameter stored in the implantable pulse generator.
18. The method of claim 10 wherein one or more electrodes of the medical lead are disposed within the epidural space of the patient between T1 and T12 vertebral levels.