Apparatus and methods for assisted breathing by transvascular nerve stimulation
A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient's left phrenic nerve and the distal electrodes may stimulate a patient's right phrenic nerve.
1. A catheter, comprising:
an elongated tubular member having a plurality of separate lumens extending along a length of the elongated tubular member, the elongated tubular member including a first plurality of apertures in an exterior wall of the elongated tubular member and a second plurality of apertures in the exterior wall, wherein the second plurality of apertures is located distal to the first plurality of apertures;
proximal electrodes located within the elongated tubular member, wherein each of the proximal electrodes is positioned radially inward of a corresponding one of the first plurality of apertures, and wherein a first elongated electrode assembly positioned in a first lumen of the plurality of lumens supports a first plurality of the proximal electrodes, and a second elongated electrode assembly positioned in a second lumen of the plurality of lumens supports a second plurality of the proximal electrodes; and
distal electrodes located within the elongated tubular member, wherein each of the distal electrodes is positioned radially inward of a corresponding one of the second plurality of apertures, and wherein a third elongated electrode assembly positioned in a third lumen of the plurality of lumens supports a first plurality of the distal electrodes, and a fourth elongated electrode assembly positioned in a fourth lumen of the plurality of lumens supports a second plurality of the distal electrodes.
2. The catheter of claim 1 , wherein the elongated tubular member is configured to be inserted into a venous system of a patient so that the proximal electrodes are proximate a left phrenic nerve, and the distal electrodes are proximate a right phrenic nerve.
3. The catheter of claim 1 , wherein the first elongated electrode assembly includes a first plurality of elongated conductive members, wherein each electrode of the first plurality of the proximal electrodes is electrically coupled to a corresponding one of the first plurality of elongated conductive members.
4. The catheter of claim 3 , wherein the second elongated electrode assembly includes a plurality of second elongated conductive members, wherein each electrode of the second plurality of the proximal electrodes is electrically coupled to a corresponding one of the second plurality of elongated conductive members.
5. The catheter of claim 4 , wherein the third elongated electrode assembly includes a plurality of third elongated conductive members, wherein each electrode of the first plurality of the distal electrodes is electrically coupled to a corresponding one of the third plurality of elongated conductive members, and the fourth elongated electrode assembly includes a plurality of fourth elongated conductive members, wherein each electrode of the second plurality of the distal electrodes is electrically coupled to a corresponding one of the fourth plurality of elongated conductive members.
6. The catheter of claim 1 , wherein the proximal electrodes include bipolar electrode pairs positionable to stimulate a left phrenic nerve, and the distal electrodes include bipolar electrode pairs positionable to stimulate a right phrenic nerve.
7. The catheter of claim 1 , wherein a pair of the proximal electrodes includes bipolar electrodes configured to stimulate a first nerve, and a pair of the distal electrodes includes bipolar electrodes configured to stimulate a second nerve.
8. The catheter of claim 1 , wherein bipolar electrode pairs of the proximal electrodes are configured to be selectively activated to create an electrical field extending radially outwards from only a portion of a circumference of a longitudinal section of the catheter that includes the proximal electrodes, and bipolar electrode pairs of the distal electrodes are configured to be selectively activated to create an electrical field extending radially outwards from only a portion of the circumference of a longitudinal section of the catheter that includes the distal electrodes.
9. The catheter of claim 1 , wherein electrodes supported by the first electrode assembly are aligned along a single longitudinal axis of the first lumen.
10. The catheter of claim 1 , wherein each of the proximal and distal electrodes is electrically coupled to a corresponding elongated conductive member.
11. The catheter of claim 1 , wherein at least one of the plurality of separate lumens is configured to receive at least one of a guidewire or fluid.