Anti-CD38 antibodies
View Patent ↗Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.
1. An isolated nucleic acid encoding the heavy chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the heavy chain variable region comprises SEQ ID NO:9.
2. An isolated nucleic acid encoding the light chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the light chain variable region comprises SEQ ID NO:10.
3. An isolated nucleic acid composition comprising:
i) a first nucleic acid encoding a heavy chain variable region comprising:
i) a first CDR comprising SEQ ID NO:3;
ii) a second CDR comprising SEQ ID NO:4;
iii) a third CDR comprising SEQ ID NO:5; and
ii) a second nucleic acid encoding a light chain variable region comprising:
i) a first CDR comprising SEQ ID NO:6;
ii) a second CDR comprising SEQ ID NO:7;
iii) a third CDR comprising SEQ ID NO:8.
4. An isolated nucleic acid composition according to claim 3 wherein said first nucleic acid encodes SEQ ID NO:9 and said second nucleic acid encodes SEQ ID NO:10.
5. An isolated nucleic acid composition according to claim 4 wherein said first nucleic acid encodes SEQ ID NO:21 and said second nucleic acid encodes SEQ ID NO:22.
6. A host cell comprising the isolated nucleic acid of claim 3 .
7. A host cell comprising the isolated nucleic acid of claim 4 .
8. A host cell comprising the isolated nucleic acid of claim 5 .
9. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 6 under conditions wherein said antibody is produced.
10. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 7 under conditions wherein said antibody is produced.
11. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 8 under conditions wherein said antibody is produced.
12. An isolated nucleic acid encoding the heavy chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the heavy chain variable region comprises:
i) a first CDR comprising SEQ ID NO:13;
ii) a second CDR comprising SEQ ID NO:14;
iii) a third CDR comprising SEQ ID NO:15.
13. An isolated nucleic acid encoding the light chain of an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) wherein the light chain variable region comprises:
i) a first CDR comprising SEQ ID NO:16;
ii) a second CDR comprising SEQ ID NO:17;
iii) a third CDR comprising SEQ ID NO:18.
14. An isolated nucleic acid encoding the heavy chain of an antibody according to claim 12 wherein said heavy chain comprises SEQ ID NO:11.
15. An isolated nucleic acid encoding the light chain of an antibody according to claim 13 wherein said light chain comprises SEQ ID NO:12.
16. An isolated nucleic acid composition comprising:
i) a first nucleic acid encoding a heavy chain variable region comprising:
i) a first CDR comprising SEQ ID NO:13;
ii) a second CDR comprising SEQ ID NO:14;
iii) a third CDR comprising SEQ ID NO:15; and
ii) a second nucleic acid encoding a light chain variable region comprising:
i) a first CDR comprising SEQ ID NO:16;
ii) a second CDR comprising SEQ ID NO:17;
iii) a third CDR comprising SEQ ID NO:18.
17. An isolated nucleic acid composition according to claim 16 wherein said first nucleic acid encodes SEQ ID NO:11 and said second nucleic acid encodes SEQ ID NO:12.
18. An isolated nucleic acid composition according to claim 17 wherein said first nucleic acid encodes SEQ ID NO:19 and said second nucleic acid encodes SEQ ID NO:20.
19. A host cell comprising the isolated nucleic acid of claim 16 .
20. A host cell comprising the isolated nucleic acid of claim 17 .
21. A host cell comprising the isolated nucleic acid of claim 18 .
22. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 19 under conditions wherein said antibody is produced.
23. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 20 under conditions wherein said antibody is produced.
24. A method of producing an antibody which specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 (SEQ ID NO:2) comprising culturing the host cell of claim 21 under conditions wherein said antibody is produced.