METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patients heart based on the three-dimensional model and the physics-based model.
1 - 184 . (canceled)
185 . A system for determining cardiovascular information for a patient, the system comprising:
at least one computer system configured to execute a method, the method comprising:
retrieving data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; and
determining boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients.
186 . The system of claim 185 , wherein determining boundary conditions tuning characteristics comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce a difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients.
187 . The system of claim 186 , wherein the data further includes invasively obtained measurements of blood flow characteristics at a plurality of anatomical locations and corresponding computed blood flow characteristics for each of the patients based on at least part on respective boundary condition models at the plurality of anatomical locations.
188 . The system of claim 186 , wherein determining the boundary conditions tuning characteristics comprises determining unique boundary conditions tuning characteristics for each of the plurality of anatomical locations.
189 . The system of claim 186 , wherein the method further comprises:
storing the boundary conditions tuning characteristics.
190 . The system of claim 186 , wherein the method further compromises:
applying the boundary conditions tuning characteristics for generating and using a patient-specific boundary condition model to computationally analyze the blood flow characteristics of an additional patient.
191 . The system of claim 190 , where the patient specific boundary conditions model represents boundaries in at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.
192 . The system of claim 186 , wherein determining boundary conditions tuning comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce the difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients at a plurality of anatomical locations.
193 . The system of claim 186 , wherein the boundary conditions tuning characteristics alter the parameters for calculating the computed blood flow characteristics.
194 . The system of claim 186 , wherein the method further comprises:
determining the accuracy of the boundary conditions tuning characteristics by applying the boundary conditions tuning characteristics to a testing pool patient data.
195 . A method for determining cardiovascular information for a patient using at least one computer system, the method comprising:
retrieving, using at least one processor, data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; and
determining, using the at least one processor, boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients.
196 . The method of claim 195 , wherein determining boundary conditions tuning characteristics comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce a difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients.
197 . The method of claim 196 , wherein the data further includes invasively obtained measurements of blood flow characteristics at a plurality of anatomical locations and corresponding computed blood flow characteristics for each of the patients based on at least part on respective boundary condition models at the plurality of anatomical locations.
198 . The method of claim 196 , wherein determining the boundary conditions tuning characteristics comprises determining unique boundary conditions tuning characteristics for each of the plurality of anatomical locations.
199 . The method of claim 196 , further comprising:
storing the boundary conditions tuning characteristics.
200 . The system of claim 196 , further compromising:
applying the boundary conditions tuning characteristics for generating and using a patient-specific boundary condition model to computationally analyze the blood flow characteristics of an additional patient.
201 . The method of claim 200 , where the patient specific boundary conditions model represents boundaries in at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.
202 . The method of claim 196 , wherein determining boundary conditions tuning comprises determining boundary conditions tuning characteristics that tune the respective boundary conditions to reduce the difference between the computed blood flow characteristics and the invasively obtained measurements of blood flow characteristics of each of the patients at a plurality of anatomical locations.
203 . The method of claim 196 , wherein the boundary conditions tuning characteristics alter the parameters for calculating the computed blood flow characteristics.
204 . A non-transitory computer readable medium for use on at least one computer system containing computer-executable programming instructions for performing a method for determining cardiovascular information for a patient, the method comprising:
retrieving data for each of a plurality of patients, the data including an invasively obtained measurement of blood flow characteristic and a blood flow characteristic computed based at least in part on a respective boundary condition; and
determining boundary conditions tuning characteristics by iteratively comparing computed blood flow characteristics to invasively obtained measurements of blood flow characteristics of each of the patients,
determining the accuracy of the boundary conditions tuning characteristics by applying the boundary conditions tuning characteristics to a testing pool patient data.