Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides

1. A compound having the structure:

or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, and wherein

R 2 is selected from the group consisting of hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, C 3 -C 6 cycloalkyl, C 6 -C 10 aryl, monocyclic or bicyclic heteroaryl, comprising 5- and/or 6-membered rings, (aryl)C 1 -C 6 linear or branched chain alkyl, (heteroaryl)C 1 -C 6 linear or branched chain alkyl, (heterocyclic)C 1 -C 6 linear or branched chain alkyl, (C 1 -C 6 linear or branched chain alkyl)aryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, (C 1 -C 6 linear or branched chain alkyl)heterocyclic, C 1 -C 6 linear or branched chain perfluoroalkyl, C 1 -C 6 linear or branched chain alkoxy, C 1 -C 6 linear or branched chain perfluoroalkoxy, halogen, cyano, hydroxyl, amino, carboxy, aminocarbonyl, (C 1 -C 6 linear or branched chain alkyl)aminocarbonylamino, (C 1 -C 6 linear or branched chain alkyl)aminocarbonyl, —SOR 12 , —SO 2 R 12 , —NR 13 SO 2 R 12 , —SO 2 NR 13 R 14 , and —NR 13 SO 2 NR 14 R 15 ; where said alkyl, aryl and heteroaryl is independently optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, cyano, alkylamino, dialkylamino, CF 3 , aminocarbonyl, (C 1 -C 6 linear or branched chain alkyl)aminocarbonyl, and C 3 -C 6 cycloalkyl;

R 3 is selected from the group consisting of hydrogen, deuterium, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, halogen, and cyano;

R a , R b , R c and R d are independently selected from hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, alkylaryl, (aryl)C 1 -C 6 linear or branched chain alkyl, (heteroaryl)C 1 -C 6 linear or branched chain alkyl, heteroaryl, halogen, cyano, hydroxyl, C 1 -C 6 linear or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic)C 1 -C 6 linear or branched chain alkyl, (C 1 -C 6 linear or branched chain alkyl)aryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, and (C 1 -C 6 linear or branched chain alkyl)heterocyclic, where said alkyl is further optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF 3 , and C 3 -C 6 cycloalkyl;

R 0 , R 1 , R 4 , R 6 , R 8 , R 9 and R 10 are independently selected from hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, C 6 -C 10 aryl, monocyclic or bicyclic heteroaryl, comprising 5- and/or 6-membered rings, (aryl)C 1 -C 6 linear or branched chain alkyl, (heteroaryl)C 1 -C 6 linear or branched chain alkyl, heteroaryl, halogen, hydroxyl, C 1 -C 6 linear or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic)C 1 -C 6 linear or branched chain alkyl, (C 1 -C 6 linear or branched chain alkyl)aryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, and (C 1 -C 6 linear or branched chain alkyl)heterocyclic, where said alkyl is further optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF 3 , and C 3 -C 6 cycloalkyl; where, alternatively, R 0 or R 1 , and/or R 6 , respectively together with either of R 4 , R a , R b , R c or R d , may independently form a bond or a C 1 -C 6 linear alkyl chain; and/or, alternatively, R 4 , respectively together with either of R a , R b , R c or R d , may independently form a bond or a C 1 -C 6 linear alkyl chain; and/or, alternatively, R 8 and R 9 may together form a 3-6-membered ring optionally containing one or two O or N atoms;

Z is N;

R 11 is hydrogen and,

R 12 , R 13 , R 14 and R 15 are independently selected from hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, C 6 -C 10 aryl, alkylaryl, and (aryl)C 1 -C 6 linear or branched chain alkyl.

2. The compound of claim 1 having the structure:

or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, and wherein

R 2 is hydrogen;

R 3 is hydrogen;

R a , R b , R c and R d are independently selected from hydrogen, C 1 -C 6 linear or branched chain alkyl, C 1 -C 6 linear or branched chain perfluoroalkyl, alkylaryl, (aryl)C 1 -C 6 linear or branched chain alkyl, (heteroaryl)C 1 -C 6 linear or branched chain alkyl, heteroaryl, halogen, cyano, hydroxyl, C 1 -C 6 linear or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic)C 1 -C 6 linear or branched chain alkyl, (C 1 -C 6 linear or branched chain alkyl)aryl, (C 1 -C 6 linear or branched chain alkyl)heteroaryl, and (C 1 -C 6 linear or branched chain alkyl)heterocyclic, where said alkyl is further optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF 3 , and C 3 -C 6 cycloalkyl;

R 0 , R 1 , R 4 , R 6 , R 8 , R 9 and R 10 are hydrogen; and,

R 11 is hydrogen.

3. The compound of claim 1 selected from the group consisting of:

(R)-1-(3-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

1-((2S,5R)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-methylpiperidin-1-yl)prop-2-en-1-one;

1-((3R,5S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-5-hydroxypiperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

1-(5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-(hydroxymethyl)piperidin-1-yl)prop-2-en-1-one;

1-((3R,5S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-5-fluoropiperidin-1-yl)prop-2-en-1-one;

1-((3R,4S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-methylpiperidin-1-yl)prop-2-en-1-one;

1-((3S,4R)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-fluoropiperidin-1-yl)prop-2-en-1-one;

1-((2S,5R)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-ethylpiperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(3-chloro-1 H-pyrrolo[2,3-b]pyridin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

1-((3R,5R)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylam ino)-5-fluoropiperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

1-((3R,5S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylam ino)-5-methylpiperidin-1-yl)prop-2-en-1-one;

1-((2S,5R)-5-(5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-methylpiperidin-1-yl)prop-2-en-1 -one;

1-((3R,5S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-5-methylpiperidin-1 -yl)prop-2-en-1-one;

1-((3R,4S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-4-methylpiperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

1-((2S,5R)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-methylpiperidin-1-yl)prop-2-en-1-one;

(R)-1-(3-(5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one;

(R)-4-(1-acryloylpiperidin-3-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; and,

(3R,5R)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-acryloylpiperidine-3-carbonitrile; or, a pharmaceutically acceptable salt thereof.

4. A compound of claim 1 wherein the compound is 1-(3R,4S)-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)prop-2-en-1-one, or a pharmaceutically acceptable salt thereof.

5. A compound of claim 1 wherein the compound is 1-((2S,5R)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2-methylpiperidin-1-yl)prop-2-en-1-one; or, a pharmaceutically acceptable salt thereof.

6. A pharmaceutical or a veterinary composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.