IP Library Granted Patent US 9,869,631
Granted Patent B2
US 9,869,631 · App. 14/563,318 · Granted Jan 16, 2018

Analysis device and method of determining mounted state of cartridge of the analysis device

Inventors: Jeong-min Jo (Suwon-si, KR); Tae-soo Kim (Yongin-si, KR); Sung-hwa Lee (Anyang-si, KR); Hyun-soo Jang (Uiwang-si, KR)
Assignee: SAMSUNG ELECTRONICS CO., LTD.
G01N21/13G01N2201/0256
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Quick Facts
Patent No.
US 9,869,631
App. No.
14/563,318
Granted
Jan 16, 2018
Kind
B2
Abstract

Disclosed are an analysis device and a method of determining a mounted state of a cartridge mounted in the analysis device. The analysis device includes: a mounting unit configured to mount a cartridge on which at least one well for containing a specimen is formed; a measuring unit configured to measure at least one signal corresponding to the at least one well formed on the cartridge; and an operation processor configured to process the at least one measured signal with respect to the at least one well measured by the measuring unit, wherein the operation processor determines a mounted state of the cartridge based on the at least one measured signal with respect to the at least one well formed on the cartridge.

Claims (45)

1. An analysis device, comprising:

a mounting unit configured to receive a cartridge on which at least one well for containing a specimen is formed;

a measuring unit configured to measure at least one signal corresponding to the at least one well formed on the cartridge; and

an operation processor configured to process the at least one measured signal with respect to the at least one well measured by the measuring unit,

wherein the operation processor configured to determine a mounted state of the cartridge based on the at least one measured signal, and

wherein the at least one well comprises a plurality of wells, the at least one signal comprises a plurality of signals, and the operation processor is configured to determine the mounted state of the cartridge based on a deviation among the plurality of signals.

2. The analysis device of claim 1 , wherein the at least one signal is at least one optical signal.

3. The analysis device of claim 2 , wherein the measuring unit comprises a light source unit configured to irradiate light to the at least one well formed on the cartridge, and a photodetector configured to detect the at least one optical signal from the light irradiated to the at least one well formed on the cartridge.

4. The analysis device of claim 3 , wherein the light source unit comprises a first light source configured to emit a first wavelength band of light and a second light source configured to emit a second wavelength band of light, different from the first wavelength band, wherein the second wavelength band is unaffected by a reagent and a specimen contained in the at least one well;

wherein the operation processor is configured to determine the mounted state of the cartridge based on the at least one measured signal obtained from the light irradiated by the second light source.

5. The analysis device of claim 1 , wherein:

the plurality of wells comprises a specimen well and a reference measurement well; and

the operation processor is configured to determine the mounted state of the cartridge based on a deviation between a measured signal with respect to the specimen well and a measured signal with respect to the reference measurement well.

6. The analysis device of claim 1 , wherein the at least one measured signal comprises a plurality of measured signals, and the operation processor is configured to determine the mounted state of the cartridge based on at least one of: a difference in absolute values among the plurality of measured signals; a ratio of a maximum value among the plurality of measured signals to a minimum value among the plurality of measured signals; a difference between the maximum value among the plurality of measured signals and the minimum value among the plurality of measured signals; an average deviation of the plurality of measured signals; and a standard deviation of the plurality of measured signals.

7. The analysis device of claim 1 , wherein the at least one signal comprises the plurality of signals, respectively corresponding to the plurality of wells, and the operation processor is configured to determine the mounted state of the cartridge based on at least one of a plurality of measured signals.

8. The analysis device of claim 1 , wherein when the deviation among the plurality of signals is within a reference range, the operation processor determines that the cartridge is properly mounted, and when the deviation among the plurality of signals is outside the reference range, the operation processor determines that the cartridge is improperly mounted.

9. The analysis device of claim 1 , further comprising a memory configured to store information with respect to a kind of the cartridge,

wherein the operation processor is configured to determine the mounted state of the cartridge based on the at least one measured signal and a reference, wherein the reference is set according to the information stored in the memory with respect to the kind of the cartridge.

10. The analysis device of claim 1 , further comprising a display unit configured to display the mounted state of the cartridge.

11. A method of determining a mounted state of a cartridge mounted in an analysis device, the method comprising:

mounting a cartridge, on which at least one well for containing a specimen is formed, in the analysis device;

measuring at least one signal corresponding to the at least one well formed on the cartridge; and

determining a mounted state of the cartridge based on the at least one measured signal.

wherein the at least one well comprises a plurality of wells, the measuring comprises measuring a plurality of signals corresponding to the plurality of wells, and the determining comprises determining the mounted state of the cartridge based on a deviation among the plurality of measured signals.

12. The method of claim 11 , wherein the at least one measured signal is at least one optical signal.

13. The method of claim 11 , wherein the measuring the plurality of signals comprises:

sequentially scanning and irradiating light onto the plurality of wells; and

detecting the plurality of optical signals from the light irradiated onto the plurality of wells.

14. The method of claim 13 , wherein the irradiating light onto the plurality of wells comprises irradiating light having a wavelength that is unaffected by a reagent and a specimen contained in the plurality of wells.

15. The method of claim 11 , wherein the plurality of wells comprises a specimen well and a reference measurement well;

the measuring comprises measuring a signal corresponding to the specimen well and measuring a signal corresponding to the reference measurement well; and

the determining comprises determining the mounted state of the cartridge based on a deviation between the measured signal corresponding to the specimen well and the measured signal with respect to the reference measurement well.

16. The method of claim 11 , wherein

the determining the mounted state of the cartridge comprises determining the mounted state based on at least one of: a difference among absolute values of the plurality of measured signals, a ratio of a maximum value of the plurality of measured signals to a minimum value of the plurality of measured signals; a difference between the maximum value of the plurality of measured signals and the minimum value of the plurality of measured signals; an average deviation of the plurality of measured signals; and a standard deviation of the plurality of measured signals.

17. The method of claim 11 , wherein the measuring comprises measuring the plurality of signals corresponding to the plurality of wells, and the determining comprises determining the mounted state of the cartridge based on at least one of the plurality of measured signals.

18. The method of claim 11 , wherein the determining the mounted state of the cartridge comprises determining that the cartridge is properly mounted when the deviation is within a reference range, and determining that the cartridge is improperly mounted when the deviation is outside the reference range.

19. The method of claim 11 , further comprising storing, in a memory, information with respect to a kind of the cartridge;

wherein the determining the mounted state of the cartridge comprises determining the mounted state of the cartridge based on the at least one measured signal and a reference, wherein the reference is set according to the information stored in the memory with respect to the kind of the cartridge.

20. The method of claim 11 , further comprising displaying the mounted state of the cartridge.

21. A method of detecting a mounted state of a cartridge, the method comprising:

irradiating light onto a plurality of wells formed on a cartridge mounted in an analysis device;

detecting light transmitted through the plurality of wells;

determining the mounted state of the cartridge based on the detected light,

wherein the detecting the light comprises measuring a first optical signal transmitted through a first one of the plurality of wells and measuring a second optical signal transmitted through a second one of the plurality of wells; and

wherein the determining the mounted state comprises determining the mounted state of the cartridge based on a comparison between the first optical signal and the second optical signal.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2022
From: SAMSUNG ELECTRONICS CO., LTD.
To: PRECISION BIOSENSOR INC.
Reel/Frame 060632/0598 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2014
From: JO, JEONG-MIN; KIM, TAE-SOO; LEE, SUNG-HWA; JANG, HYUN-SOO
To: SAMSUNG ELECTRONICS CO., LTD.
Reel/Frame 034482/0522 →
Priority Claims (1)
KR 10-2014-0011732 · Jan 29, 2014 · national
Continuity (2)
Provisional Application 61977987 · Apr 10, 2014
Related Publication 20150211994A1 · Jul 30, 2015