Treatment and diagnosis of inflammatory disorders and HIV
View Patent ↗This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of reducing the level of HIV-1 infected white blood cells in a mammalian subject having the infection, the method comprising:
(a) identifying a mammalian subject having the HIV-1 infection and
(b) administering to the subject a composition comprising a therapeutically effective amount of an isolated leukotoxin comprising SEQ ID NO: 1, thereby reducing the level of the HIV-1 infected cells in the mammalian subject, wherein the HIV-1-infected cells express upregulated and activated leukocyte function antigen (LFA-1) on their surface to which the leukotoxin specifically binds.
2. The method of claim 1 , wherein the HIV-1 infected cells are peripheral blood mononuclear cells and CD4+ T cells.
3. The method of claim 1 , wherein the leukotoxin is obtained from Aggregatibacter actinomycetemcomitans.
4. The method of claim 1 , wherein the leukotoxin is purified.
5. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
6. The method of claim 1 , wherein the method further comprises administering to the subject an anti-HIV agent.