Antimicrobial compounds
View Patent ↗Provided are compounds which are useful for controlling microorganisms in aqueous or water-containing systems or in systems which are exposed to moisture, including at elevated temperature. The antimicrobial compounds are of the formula I: wherein n, R 1 , R 2 , R 3 , and X are as defined herein.
1. A compound of formula I:
wherein n is 0 or 1; R 1 , R 2 , and R 3 are independently H, linear or branched C 1 -C 10 alkyl, or C 3 -C 8 cycloalkyl, or R 2 and R 3 together with the carbon to which they are attached form C 3 -C 8 cycloalkyl; and X is O or NR 4 , wherein R 4 is H or C 1 -C 6 alkyl, provided that the compound is not 2,3,4,8,9,9a-hexahydropyrido[2,1-b][1,3]oxazine.
2. The compound of claim 1 wherein R 1 is H, and R 2 and R 3 are independently linear or branched C 1 -C 10 alkyl.
3. The compound of claim 1 wherein R 3 is H, and R 1 and R 2 are independently linear or branched C 1 -C 10 alkyl.
4. The compound of claim 1 wherein n is 0.
5. The compound of claim 1 wherein X is O.
6. The compound of claim 1 that is: 2-butyl-3-ethyl-3,7,8,8a-tetrahydro-2H -oxazolo[3,2-a]pyridine; 2′,7′,8′,8a′-tetrahydrospiro[cyclohexane-1,3′-oxazolo[3,2-a]pyridine];2-(heptan-3-yl)-3-methyl-3,7,8,8a-tetrahydro-2H-oxazolo[3,2-a]pyridine; 2,3-dimethyl-3,7,8,8a-tetrahydro-2H-oxazolo[3,2-a]pyridine; 3,3-dimethyl-3,7,8,8a-tetrahydro-2H-oxazolo[3,2-a]pyridine; or 2-ethyl-2,3,4,8,9,9a-hexahydro-1H-pyrido[1,2-a]pyrimidine.