IP Library › Patent Application 14566695
Patent Application
App. No. 14/566,695

METHODS AND COMPOSITIONS FOR ENHANCING DELIVERY OF DOUBLE-STRANDED RNA OR A DOUBLE-STRANDED HYBRID NUCLEIC ACID TO REGULATE GENE EXPRESSION IN MAMMALIAN CELLS

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Quick Facts
Patent No.
US None
App. No.
14/566,695
Abstract

A delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:11 or salt thereof. This invention is directed towards methods and compositions to administer a double-stranded ribonucleic acid to a mammal so as to effectuate transfection of the double-stranded RNA into a desired tissue of the mammal.

Claims (9)

1 . A delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:11 or salt thereof.

2 . The delivery-enhancing peptide of claim 1 , wherein the delivery-enhancing peptide is modified by incorporation of one or more amino—and/or carboxy—terminal chemical modifications.

3 . The delivery-enhancing peptide of claim 2 , wherein the one or more amino—and/or carboxy—terminal chemical modifications are selected from the group consisting of an amide, BrAc, and maleimide group.

4 . A composition comprising a delivery-enhancing peptide comprising the amino acid sequence of SEQ ID NO:11 or salt thereof, and a nucleic acid.

5 . The composition of claim 4 , wherein the nucleic acid is a single stranded nucleic acid or a double-stranded nucleic acid.

6 . The composition of claim 4 , wherein the nucleic acid comprises RNA and/or DNA.

7 . The composition of claim 4 , wherein the nucleic acid is an siRNA or siHyrbid.

8 . The composition of claim 4 , wherein the delivery-enhansing peptide is in a complex with the nucleic acid or is conjugated to the nucleic acid.

12 . The composition of claim 4 further comprising a surfactant, liposome, long chain amphipathic molecule, cyclodextrin, chelating agent, amino acid, or salt thereof, or any combination thereof.