Human protein tyrosine phosphatase inhibitors and methods of use
View Patent ↗The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis.
1. A compound of the formula:
R is a thiazolyl group that is substituted or unsubstituted;
R 1 is alkyl, phenyl, or benzyl, any of which is substituted or unsubstituted, or hydrogen;
R 2 is alkyl or alkoxy; and
R 3 is hydrogen or alkyl,
or a pharmaceutically-acceptable salt thereof.
2. The compound of claim 1 , wherein:
each instance of alkyl is independently C 1 -C 6 linear alkyl, C 3 -C 6 branched alkyl, or C 3 -C 6 cyclic alkyl; and
alkoxy is C 1 -C 6 linear alkoxy or C 3 -C 6 branched alkoxy.
3. The compound of claim 1 , wherein R 1 is substituted or unsubstituted phenyl.
4. The compound of claim 1 , wherein R 1 is substituted or unsubstituted benzyl.
5. The compound of claim 1 , wherein R 2 is alkyl.
6. The compound of claim 1 , wherein R 2 is alkoxy.
7. The compound of claim 1 , wherein R 2 is methoxy.
8. The compound of claim 1 , wherein R 3 is hydrogen.
9. The compound of claim 1 , wherein R is:
wherein R 6 is alkyl, phenyl, or heteroaryl, any of which is substituted or unsubstituted, or hydrogen.
10. The compound of claim 9 , wherein R 6 is alkyl.
11. The compound of claim 9 , wherein R 6 is substituted or unsubstituted heteroaryl.
12. The compound of claim 9 , wherein R 6 is substituted or unsubstituted thiophen-2-yl.
13. A pharmaceutical composition comprising:
a) a compound of the formula:
R is a thiazolyl group that is substituted or unsubstituted;
R 1 is alkyl, phenyl, or benzyl, any of which is substituted or unsubstituted, or hydrogen;
R 2 is alkyl or alkoxy; and
R 3 is hydrogen or alkyl,
or a pharmaceutically-acceptable salt thereof; and
b) a pharmaceutically-acceptable excipient.
14. The compound of claim 1 , wherein the compound is:
15. The compound of claim 1 , wherein the compound is:
16. The pharmaceutical composition of claim 13 , wherein the compound is:
17. The pharmaceutical composition of claim 13 , wherein the compound is: