Compounds and methods for treating bacterial infections
The present invention encompasses compounds and methods for treating urinary tract infections.
1. A compound of Formula (XXI):
wherein:
X is selected from the group consisting of hydrogen, OD 2 , SD 2 , and ND Z ;
Z is selected from the group consisting of O, S, CD 3 and ND 4 ;
Y is selected from the group consisting of oxygen, sulfur, CD 3 , ND 4 , —N(D 18 )CO—, —CH 2 N(D 18 )-, —CH 2 N(D 18 )CO—, CO 2 , SO 2 , —CH 2 O—, —CH 2 S—, CO, —CON(D 18 )-, —SO 2 N(D 18 )-, —O(CH 2 )n-, —S(CH 2 )n-, —N(CH 2 )n-, —(CH 2 )n-, ND 5 , and an optionally substituted alkyl, alkene, alkyne, or heterocycle;
n is an integer from 1 to 10;
D 2 , D 3 , D 4 are independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
D 10 is selected from the group consisting of CF 3 , halogen, CH 3 , OMe, hydrocarbyl, and substituted hydrocarbyl;
D 11 and D 12 form an optionally substituted cycloalkyl or heterocyclo ring, D 12 and D 13 form an optionally substituted cycloalkyl or heterocyclo ring, or D 13 and D 14 form an optionally substituted cycloalkyl or heterocyclo ring;
D 18 is independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
D z is independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, —COD x , —COND x D x SO 2 D x , and —CO 2 D x ; and
D x is independently selected from the group consisting of hydrogen, —ND 4 D 5 , and an optionally substituted alkyl, cycloalkyl, heterocyclo, or aryl.
2. The compound of claim 1 , wherein X is OD 2 .
3. The compound of claim 2 , wherein Y is selected from the group consisting of oxygen, sulfur, CD 3 , ND 4 , —N(D 18 )CO—, —CH 2 N(D 18 ), and an optionally substituted alkyl.
4. The compound of claim 3 , wherein D 10 is selected from the group consisting of CF 3 , halogen, CH 3 , OMe.
5. The compound of claim 4 , wherein D 12 and D 13 form an optionally substituted cycloalkyl or heterocyclo ring.
6. A method of treating a urinary tract infection, the method comprising administering a compound of claim 1 to a subject in need thereof.
7. The method of claim 6 , wherein the subject is further administered a bactericidal composition.
8. A method of reducing the resistance of a bacterium to a bactericidal compound, the method comprising administering a compound of claim 1 to a subject in need thereof.