Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
View Patent ↗The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
1. A nitric oxide-releasing particle comprising:
a co-condensed silica network comprising methylaminopropyl trimethoxysilane (MAP3) and tetra methyl orthosilicate (TMOS), wherein the MAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the MAP3 comprises N-diazeniumdiolate functionalized MAP3.
2. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 10% to 75%.
3. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 1% to 90%.
4. The nitric oxide-releasing particle of claim 1 , wherein the MAP3 is present in a mol % of 45% to 55%.
5. The nitric oxide-releasing particle of claim 4 , wherein the MAP3 is present in a mol % of about 50%.
6. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized MAP3 comprises a sodium cation.
7. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized MAP3 comprises a potassium cation.
8. The nitric oxide-releasing particle of claim 1 , wherein the N-diazeniumdiolate functionalized MAP3 comprises a lithium cation.
9. The nitric oxide-releasing particle of claim 3 , wherein the TMOS is present in a mol % of 10% to 99%.