IP Library › Granted Patent US 9,434,703
Granted Patent B2
US 9,434,703 · App. 14/577,380 · Granted Sep 6, 2016

Viloxazine compositions

Inventors: Likan Liang (Boyds, MD); Padmanabh P. Bhatt (Rockville, MD); David Dain (Baltimore, MD); Jean-Philippe Taquet (Lugrin, FR); Aleksandr Pechenov (Germantown, MD); Alexei Tchesnokov (Germantown, MD); Reynold Mariaux (Vionnaz, CH)
Assignee: Supernus Pharmaceuticals, Inc.
C07D265/30C07C215/08C07C217/34C07D265/32
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Quick Facts
Patent No.
US 9,434,703
App. No.
14/577,380
Granted
Sep 6, 2016
Kind
B2
Abstract

Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

Claims (5)

1. A compound having the Formula 4 or Formula 5:

2. A composition comprising a compound having Formula 4 or Formula 5:

3. The composition according to claim 2 , wherein the compound having Formula 4 or Formula 5 is present in an amount less than about 2.5 ppm.

4. The composition according to claim 2 , further comprising viloxazine having the Formula 1 or Formula 2 or a pharmaceutically acceptable salt thereof:

5. The composition according to claim 3 , further comprising viloxazine having the Formula 1 or Formula 2 or a pharmaceutically acceptable salt thereof:

Assignments (2)
RELEASE OF SECURITY INTEREST Recorded Nov 30, 2017
From: U.S. BANK NATIONAL ASSOCIATION
To: SUPERNUS PHARMACEUTICALS, INC.
Reel/Frame 044552/0694 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2015
From: LIANG, LIKAN; BHATT, PADMANABH; DAIN, DAVID; TAQUET, JEAN-PHILIPPE; PECHENOV, ALEXSANDR; TCHESNOKOV, ALEXEI; MARIAUX, REYNOLD
To: SUPERNUS PHARMACEUTICALS, INC.
Reel/Frame 035405/0945 →
Continuity (3)
Continuation 13084612 · Apr 12, 2011
Provisional Application 61323151 · Apr 12, 2010
Related Publication 20150126735A1 · May 7, 2015