Magnetic system for particle attraction in a plurality of chambers
The invention relates to a magnetic sample-processing device, particularly a sensor device ( 100 ), that comprises two electromagnets ( 110, 120 ) for generating a magnetic field (B) in a first and a second sample chamber (SC 1 , SC 2 ) located adjacent to each other in an x-direction. The poles of the electromagnets are disposed below the first and the second sample chamber (SC 1 , SC 2 ), respectively, next to each other in a perpendicular y-direction. Moreover, the electromagnets are individually controlled by a control unit ( 130 ). In a preferred embodiment, the distance between the electromagnets ( 110, 120 ) in x-direction is so large that magnetic cross talk can be neglected. In another embodiment, said distance is close, and the electromagnets are operated in a synchronized way.
1. A sample-processing device for generating a magnetic field (B) in a first sample chamber and a second sample chamber that are located adjacent to each other in an x-direction, the sample-processing device comprising:
a) a first electromagnet having a first pair of poles disposed below the first sample chamber, and adjacent to the first sample chamber in a y-direction which is substantially perpendicular to the x-direction;
b) a second electromagnet having a second pair of poles disposed below the second sample chamber, and adjacent to the second sample chamber in the y-direction; and
c) a control unit configured to control the first electromagnet and the second electromagnet individually.
2. A method for processing a sample with a sample-processing device in a first sample chamber and a second sample chamber that are located adjacent to each other in an x-direction, the method comprising:
a) disposing below the first sample chamber a first electromagnet with a first pair of poles which are arranged next to each other in a y-direction that is substantially perpendicular to the x-direction;
b) disposing below the second sample chamber a second electromagnet with a second pair of poles that are arranged next to each other in the y-direction; and
c) controlling the first electromagnet and the second electromagnet individually to generate a magnetic field (B) in at least one of the first sample chamber and the second sample chamber.
3. The device according to claim 1 , characterized in that wherein an exchangeable cartridge hosts the first and second sample chambers.
4. The device according to claim 1 , wherein the first and the second sample chambers are physically separated from each other.
5. The device according to claim 1 , wherein at least one of the first electromagnet and the second electromagnet comprises a core with a horse-shoe shape.
6. The device according to claim 1 , wherein the pairs of poles of the first and second electromagnets, respectively, are separated in x-direction by a distance (D) that is larger than a distance (A) between the poles of one pair of poles.
7. The device according to claim 1 , wherein the pairs of poles of the first and second electromagnets, respectively, are separated in x-direction by a distance (D) that is less than half a distance (A) between the poles of one pair of poles.
8. The device according to claim 1 , wherein neighboring poles of different electromagnets are configured to have in average opposite polarity for a predetermined percentage of time.
9. The device according to claim 8 , wherein the neighboring poles of different electromagnets are configured to always have opposite polarity.
10. The device according to claim 1 , further comprising:
a sensor module for detecting particles in at least one of the first and second sample chambers, the first and second sample chambers having a sensing surface adjacent to the first and second electromagnets.
11. The device according to claim 10 , wherein the sensor module for detecting the particles comprises one of an optical, magnetic, mechanical, acoustic, thermal or electrical sensor module.
12. The device according to claim 11 , wherein the sensor module comprises a light source configured to illuminate sensing regions of both the first sample chamber and the second sample chamber, respectively.
13. The device according to claim 11 , wherein the sensor module comprises a light detector configured to measure light coming from sensing regions of both the first sample chamber and the second sample chamber, respectively.
14. The method according to claim 2 , further comprising:
performing one of molecular diagnostics, biological sample analysis, chemical sample analysis, food analysis, or forensic analysis using the processed sample.
15. The device according to claim 6 , wherein the distance (D) is greater than about 1.2 mm.
16. The device according to claim 7 , wherein the distance (D) is less than about 0.5 mm.
17. The method according to claim 2 , further comprising:
detecting particles in at least one of the first and second sample chambers at a sensing surface of the first and second sample chambers adjacent to the first and second electromagnets.
18. The method according to claim 17 , wherein detecting the particles in at least one of the first and second sample chambers comprises:
illuminating the sensing surface with an input light beam from a light source; and
measuring frustrated total internal reflection (FTIR) of the input light beam at the sensing surface.