Oligomer-opioid agonist conjugates
View Patent ↗The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
1. A compound according to the following formula:
wherein n is an integer from 1 to 30.
2. The compound of claim 1 , wherein n is 2 to 30.
3. The compound of claim 1 , wherein n is 1 to 10.
4. A composition comprising a compound of claim 1 , and optionally, a pharmaceutically acceptable excipient.
5. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.
6. A method of treating pain in a subject comprising administering a compound of claim 1 to the subject.
7. A compound comprising a residue of oxymorphone covalently attached to a poly(ethylene oxide).
8. The compound of claim 7 , wherein the poly(ethylene oxide) is made of between 1 and 30 monomers.
9. The compound of claim 8 , wherein the poly(ethylene oxide) is made of between 1 and 10 monomers.
10. The compound of claim 7 , wherein the poly(ethylene oxide) includes an alkoxy or hydroxy end-capping moiety.
11. The compound of claim 7 , wherein a single poly(ethylene oxide) is attached to the residue of oxymorphone.
12. A composition comprising a compound of claim 7 , and optionally, a pharmaceutically acceptable excipient.
13. A composition of matter comprising a compound of claim 7 , wherein the compound is present in a dosage form.
14. A method of treating pain in a subject comprising administering a compound of claim 7 to the subject.