Method for treating a tubular anatomical structure

1. A method for treating nerve cells around a tubular anatomical structure, the method comprising;

advancing into the tubular anatomical structure a catheter having at least one electrode, the at least one electrode including a set of electrodes;

positioning the advanced electrode near a target area containing at least one nerve cell without piercing the target area;

applying, using the positioned electrode, an electrical treatment signal in an amount sufficient to destroy the at least one nerve cell in the target area, wherein the electrical treatment signal includes applying a plurality of rectangular electrical pulses to cause an electric field, wherein the plurality of electrical pulses is distributed among the set of electrodes through a switching circuit.

2. The method of claim 1 , wherein the step of applying an electrical treatment signal includes applying a plurality of electrical signals in a direction substantially along the length of the at least one nerve cell.

3. The method of claim 1 , wherein the electric field is in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the at least one nerve cell, thereby killing the nerve cell.

4. The method of claim 1 , wherein each electrical pulse has a duration of at least 10 microseconds.

5. The method of claim 1 , wherein each electrical pulse has an amplitude of at least 1000 Volts/cm.

6. The method of claim 1 , wherein the at least ons electrode comprises a plurality electrodes.

7. The method of claim 1 , further comprising cooling the tubular anatomical structure to a temperature in the range of 10 to 20 degrees Celsius.

8. The method of claim 1 , further comprising placing at least one temperature sensor in the vicinity of the electrode for use in monitoring temperature.

9. The method of claim 1 , wherein the step of applying includes applying the electrical current in a direction which is substantially radial to the tubular anatomical structure.

10. The method of claim 1 , further comprising determining an endpoint by monitoring the target area.

11. The method of claim 1 , further comprising determining an endpoint by monitoring the resistance of the target area.

12. The method of claim 1 , further comprising expanding a balloon to anchor the at least one electrode against the target area.

13. The method of claim 1 , further comprising expanding a balloon to anchor the at least one electrode against the target area, wherein the step of applying includes:

applying the electrical treatment signal in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.

14. The method of claim 1 , further comprising determining an endpoint by monitoring the resistance of the target area, wherein the step of applying includes:

applying the electrical treatment signal in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.

15. A method for treating nerve cells around a tubular anatomical structure, the method comprising:

advancing into a tubular anatomical structure a catheter having at least one electrode, the at least one electrode including a set of electrodes;

positioning the electrode of the advanced catheter near a target area containing at least one nerve cell around the tubular anatomical structure;

applying, through the positioned electrode, a plurality of electrical pulses with each electrical pulse being a rectangular pulse and having a duration of at least 10 microseconds and at most 500 milliseconds to cause an electric field in an amount above an upper limit of electroporation to irreversibly open pores in the at least one nerve cell, thereby killing the nerve cell in the target area, wherein the plurality of electrical pulses is distributed among the set of electrodes through a switching circuit.

16. The method of claim 15 , wherein the step of applying includes causing the electric field in a direction substantially along the length of the at least one nerve cell.

17. The method of claim 15 , wherein the step of applying includes causing the electric field in a direction which is substantially radial to the tubular anatomical structure.

18. The method of claim 15 , wherein the step of applying includes causing the electric field in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.

19. The method of claim 15 , further comprising cooling the tubular anatomical structure to a temperature in the range of 10 to 20 degrees Celsius.

20. The method of claim 15 , further comprising placing at least one temperature sensor in the vicinity of the electrode for use in monitoring temperature.

21. The method of claim 15 , further comprising determining an endpoint by monitoring the resistance of the target area.

22. The method of claim 15 , further comprising preheating, using a radio frequency generator, the target area prior to applying the plurality of electrical pulses.

23. The method of claim 15 , further comprising expanding a balloon to anchor the at least one electrode against the target area.

24. The method of claim 15 , further comprising expanding a balloon to anchor the at least one electrode against the target area, wherein the step of applying includes causing the electric field in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.

25. The method of claim 15 , further comprising determining an endpoint by monitoring the resistance of the target area, wherein the step of applying includes causing the electric field in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.

26. A method for treating nerve cells around a tubular anatomical structure, the method comprising:

advancing into the tubular anatomical structure a catheter having at least one electrode;

positioning the advanced electrode near a target area containing at least one nerve cell without piercing the target area;

preheating, using a radio frequency generator, the target area prior to applying an electrical treatment signal;

applying, using the positioned electrode, the electrical treatment signal in an amount sufficient to destroy the at least one nerve cell in the target area.