Compositions and Methods for the Treatment of Nasal Conditions
The invention provides compositions and methods for treating nasal congestion. The provided compositions and methods utilize low concentrations of selective a-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
1 . A composition comprising from about 0.01% to about 0.04% w/v brimonidine and a vehicle selected from one or more cellulosic vehicles and polyvinylpyrrolidone or a combination thereof, wherein w/v denotes weight by volume.
2 . The composition of claim 1 wherein brimonidine is at a concentration of about 0.035% w/v.
3 . The composition of claim 1 , wherein the one or more cellulosic vehicles are selected from carboxymethyl cellulose, microcrystalline cellulose, a mixture of carboxymethyl cellulose and microcrystalline cellulose, hydroxypropyl cellulose and hydroxpropylmethyl cellulose.
4 . The composition of claim 3 , wherein the vehicle comprises a mixture of carboxymethyl cellulose and microcrystalline cellulose, polyvinylpyrrolidone and hydroxypropyl cellulose.
5 . The composition of claim 4 wherein the concentration of hydroxypropyl cellulose is from about 0.96% to about 1.36% w/v.
6 . The composition of claim 5 wherein the concentration of hydroxypropyl cellulose is about 1.167% w/v.
7 . The composition of claim 3 comprising wherein the vehicle comprises a mixture of carboxymethyl cellulose and microcrystalline cellulose, polyvinylpyrrolidone and hydroxypropylmethyl cellulose.
8 . The composition of claim 7 wherein the concentration of hydroxypropylmethyl cellulose is from about 2% to about 4% w/v.
9 . The composition of claim 8 wherein the concentration of hydroxypropylmethyl cellulose is about 3% w/v.
10 . A method of treating a nasal condition in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of the composition of claim 1 , wherein the subject experiences minimal or no rebound.
11 . A composition comprising:
brimonidine at an amount of about 0.035% w/v;
3.0% w/v of a coprecipitate consisting of carboxymethyl cellulose and microcrystalline cellulose;
polyvinylpyrrolidone at an amount of about 3.0% w/v; and
hydroxypropyl cellulose at an amount of about 1.167% w/v,
wherein w/v denotes weight by volume.