Compositions comprising enzyme-cleavable oxycodone prodrug
View Patent ↗The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
1. N-1-[3-(Oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, Compound KC-8, shown below:
or a salt thereof.
2. The compound of claim 1 , wherein the salt is a pharmaceutically acceptable salt.
3. The compound of claim 1 , wherein the salt is an acid addition salt formed with an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl) benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethane-disulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-naphthalenesulfonic acid, 4-toluenesulfonic acid, camphorsulfonic acid, 4-methylbicyclo[2.2.2]-oct-2-ene-1-carboxylic acid, glucoheptonic acid, 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid and muconic acid.
4. The compound of claim 3 , wherein the salt is a pharmaceutically acceptable salt.
5. The compound of claim 1 , wherein the salt is a salt formed by replacement of an acidic proton with a metal ion selected from the group consisting of an alkali metal ion, an alkaline earth ion and an aluminum ion.
6. The compound of claim 5 , wherein the salt is a pharmaceutically acceptable salt.
7. A composition comprising N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, Compound KC-8, shown below:
or a salt thereof.
8. The composition of claim 7 , wherein the salt is a pharmaceutically acceptable salt.
9. The composition of claim 8 , further comprising a pharmaceutically acceptable carrier.
10. The composition of claim 9 , wherein the composition is formulated for oral administration.
11. The composition of claim 9 , wherein the composition is formulated as a tablet, capsule, thin film, powder, suspension, solution, syrup, dispersion or emulsion.
12. The composition of claim 7 , further comprising one or more of a carrier, binder, lubricant, pH modifier, sweetener, bulking agent and coloring agent.
13. The composition of claim 7 , wherein Compound KC-8 or salt thereof is present in a dose ranging from 0.01 milligrams per kilogram to 20 milligrams of Compound KC-8 or acceptable salt thereof per kilogram (mg/kg) body weight.
14. The composition of claim 13 , wherein the salt is a pharmaceutically acceptable salt.