IP Library › Granted Patent US 9,353,055
Granted Patent B2
US 9,353,055 · App. 14/594,668 · Granted May 31, 2016

Method for the purification of prostaglandins

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Quick Facts
Patent No.
US 9,353,055
App. No.
14/594,668
Granted
May 31, 2016
Kind
B2
Abstract

The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.

Claims (2)

1. A latanoprost composition comprising C11-beta isomer of latanoprost in an amount greater than 0% and less than 0.03%, and containing less than 0.03% C15R-Trans isomer of latanoprost, less than 0.05% C15S-Trans isomer of latanoprost, and less than 0.03% C15S-Cis isomer of latanoprost, after 11 months storage at freezer temperature.

2. A latanoprost composition comprising a C11-beta isomer of latanoprost in an amount greater than 0% and less than 0.03%, after 11 months storage at freezer temperature.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2022
From: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
To: MACFARLAN SMITH LIMITED
Reel/Frame 061888/0166 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2016
From: HOGAN, ROBERT R.; ROSSI, RONALD
To: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
Reel/Frame 037957/0497 →