Bioactive Grafts and Composites
Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
1 - 37 . (canceled)
38 . A malleable orthopedic implant comprising:
a chitosan solution, wherein the concentration of chitosan is less than about 2.5%, wherein the chitosan comprises a deacetylated chitosan from about 50% to about 99% to produce relatively rapid degradation when implanted, and wherein the pH level is less than about 6;
an osteostimulative agent; and
water.
39 . The implant of claim 38 , wherein the osteostimulative agent comprises a calcium salt.
40 . The implant of claim 39 , wherein the calcium salt concentration is greater than about 10%.
41 . The implant of claim 39 , wherein the calcium salt concentration is greater than about 40%.
42 . The implant of claim 38 , wherein the osteostimulative agent comprises a tissue.
43 . The implant of claim 42 , wherein the tissue is allograft tissue.
44 . The implant of claim 42 , wherein the tissue is at least partially demineralized bone.
45 . The implant of claim 38 , wherein the osteostimulative agent includes granules larger than about 100 μm.
46 . The implant of claim 45 , wherein the granules are osteoconductive.
47 . The implant of claim 38 , wherein the implant exhibits anti-microbial activity against staphylococcus aureus (MRSA).