Granted Patent
B2
US 9,181,263 · App. 14/605,854 · Granted Nov 10, 2015
Inhibitors of bruton's tyrosine kinase
Inventors:
Lee Honigberg (San Francisco, CA); Erik Verner (Belmont, CA); Joseph J. Buggy (Mountain View, CA); David Loury (Incline Village, NV); Wei Chen (Fremont, CA)
Assignee:
PHARMACYCLICS LLC
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Abstract
Described herein are irreversible kinase inhibitor compounds, exemplified by compounds of the following structure: methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of a disease such as cancer.
Claims (3)
1. An irreversible BTK inhibitor having the structure:
wherein
is a non-bicyclic heteroaryl group.
Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0368. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME.
Recorded May 18, 2016
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 038742/0371 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 036126 FRAME 0359. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER.
Recorded May 17, 2016
From: OXFORD AMHERST CORPORATION; PHARMACYCLICS, INC.
To: PHARMACYCLICS, INC.
Reel/Frame 038742/0064 →
MERGER
Recorded Jul 16, 2015
From: OXFORD AMHERST CORPORATION
To: PHARMACYCLICS, INC.
Reel/Frame 036126/0359 →
MERGER AND CHANGE OF NAME
Recorded Jul 16, 2015
From: PHARMACYCLICS, INC.; OXFORD AMHERST LLC
To: PHARMACYCLICS LLC
Reel/Frame 036126/0368 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 4, 2015
From: HONIGBERG, LEE; VERNER, ERIK J.; BUGGY, JOSEPH J.; LOURY, DAVID J.; CHEN, WEI
To: PHARMACYCLICS, INC.
Reel/Frame 034890/0079 →
Continuity (6)
Continuation
12594805
Provisional Application
61017125
· Dec 27, 2007