Substituted imidazolium compounds for treating disease
View Patent ↗The present disclosure relates to therapeutic compositions comprising substituted imidazoliums having multiple acidic groups. The compounds may be used to treat diseases or conditions such as those associated with bone, cancer, or pain. Compositions, dosage forms, methods of treating diseases or conditions, methods of preparation, and other related embodiments related to the substituted imidazoliums are also described herein.
1. A compound represented by a formula:
wherein X − is F − , Br − , Cl − , I − , OH − , or acetate; and
M + is Na + , K + , or NH 4 + .
2. The compound of claim 1 , further represented by a formula,
3. The compound of claim 2 , wherein the compound is in a hydrate form.
4. A dosage form comprising the compound of claim 1 .
5. The dosage form of claim 4 , wherein the compound is no more than 0.1% (w/w) of the total amount of therapeutically active agent in the dosage form.
6. The dosage form of claim 4 , wherein the compound is at least 20% of the total amount of therapeutically active agent in the dosage form.
7. The dosage form of claim 4 , wherein the compound is at least 90% of the total amount of therapeutically active agent in the dosage form.
8. A compound represented by a formula:
wherein M + is Na + , K + , or NH 4 + .
9. The compound of claim 8 , wherein the compound is further represented by a formula,
10. The compound of claim 9 , wherein the compound is in a hydrate form.
11. A dosage form comprising the compound of claim 8 .
12. The dosage form of claim 8 , wherein the compound is no more than 0.1% (w/w) of the total amount of therapeutically active agent in the dosage form.
13. The dosage form of claim 8 , wherein the compound is at least 20% of the total amount of therapeutically active agent in the dosage form.
14. The dosage form of claim 8 , wherein the compound is at least 90% of the total amount of therapeutically active agent in the dosage form.