Electrical stimulation treatment of hypotension
View Patent ↗The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.
1. A device for treating a patient with a disorder, the device comprising;
a power supply;
an electrical impulse generator coupled to the power supply;
one or more electrodes coupled to the electrical impulse generator and configured for placement in or on a neck of the patient at a location spaced apart from a target nerve region in the patient by a distance from about 5 millimeters (mm) to about 20 mm; and
wherein the electrical impulse generator is configured to provide an electrical impulse through the electrodes to the target nerve region.
2. The device of claim 1 , wherein the one or more electrodes is configured for placement adjacent to one or more nerves of a parasympathetic nervous system of the patient.
3. The device of claim 2 , wherein the disorder is hypotension.
4. The device of claim 2 , wherein the disorder is hypertension.
5. The device of claim 1 , wherein the electrical impulse has an amplitude from about 1 volt to about 20 volts.
6. The device of claim 1 , wherein the electrical impulse has an amplitude from about 2 volts to about 12 volts.
7. The device of claim 1 , wherein the electrical impulse has a pulsed on-time from about 50 microseconds to about 500 microseconds.
8. The device of claim 1 , wherein the target nerve region is a vagus nerve.
9. The device of claim 1 , wherein the electrical impulse has a frequency from about 10 Hertz (Hz) to about 35 Hz.
10. The device of claim 1 , wherein the electrical impulse has a frequency of about 25 Hz, a pulsed on-time of about 200 microseconds, and an amplitude of about 1 volt.
11. The device of claim 1 , wherein the electrical impulse generator is configured to alternate a polarity of the electrical impulse about every second.
12. The device of claim 1 , wherein the one or more electrodes is implantable.
13. A device for treating a patient with a disorder, the device comprising;
a power supply;
an electrical impulse generator coupled to the power supply;
one or more electrodes coupled to the electrical impulse generator and configured for placement in a natural orifice of the patient at a location spaced apart from a target nerve region in the patient by a distance from about 5 mm to about 20 mm; and
wherein the electrical impulse generator is configured to provide an electrical impulse through the electrodes to the target nerve region.
14. The device of claim 13 , wherein the one or more electrodes is configured for placement adjacent to one or more nerves of a parasympathetic nervous system of the patient.
15. The device of claim 14 , wherein the disorder is hypotension.
16. The device of claim 14 , wherein the disorder is hypertension.
17. The device of claim 13 , wherein the electrical impulse has an amplitude from about 1 volt to about 20 volts.
18. The device of claim 13 , wherein the electrical impulse has an amplitude from about 2 volts to about 12 volts.
19. The device of claim 13 , wherein the electrical impulse has a pulsed on-time from about 50 microseconds to about 500 microseconds.
20. The device of claim 13 , wherein the target nerve region is a vagus nerve.
21. The device of claim 13 , wherein the electrical impulse has a frequency from about 10 Hz to about 35 Hz.
22. The device of claim 13 , wherein the electrical impulse has a frequency of about 25 Hz, a pulsed on-time of about 200 microseconds, and an amplitude of about 1 volt.
23. The device of claim 13 , wherein the electrical impulse generator is configured to alternate a polarity of the electrical impulse about every second.
24. The device of claim 13 , wherein the one or more electrodes is implantable.