Substituted dihydropyrazolones for treating cardiovascular and hematological diseases

1. A method of treatment of a cardiovascular disease, cardiac insufficiency, anemia, a chronic kidney disease or renal insufficiency comprising administering to a human or animal in need thereof an active amount of a compound of formula (I)

in which

R 1 represents a heteroaryl group of the formula

wherein

* denotes the linkage point with the dihydropyrazolone ring

and

R 4 denotes hydrogen, fluorine, chlorine, bromine, cyano, (C 1 -C 4 )-alkyl, trifluoromethyl, hydroxymethyl, (C 1 -C 4 )-alkoxy, trifluoromethoxy, hydroxycarbonyl or (C 1 -C 4 )-alkoxycarbonyl,

R 2 represents a heteroaryl group of the formula

wherein

# denotes the linkage point with the dihydropyrazolone ring

and

R 6 , R 6A and R 6B are identical or different and independently of one another denote hydrogen or a substituent chosen from the series consisting of fluorine, chlorine, bromine, cyano, (C 1 -C 6 )-alkyl, trifluoromethyl, hydroxyl, (C 1 -C 6 )-alkoxy, trifluoromethoxy, amino, mono-(C 1 -C 4 )-alkylamino, di-(C 1 -C 4 )-alkylamino, hydroxycarbonyl, (C 1 -C 4 )-alkoxycarbonyl and 4- to 6-membered heterocycloalkyl, wherein

 (C 1 -C 6 )-alkyl in its turn can be substituted by hydroxyl, (C 1 -C 4 )-alkoxy or amino

 and

 4- to 6-membered heterocycloalkyl in its turn can be substituted once or twice in an identical or different manner by fluorine, cyano, (C 1 -C 4 )-alkyl, trifluoromethyl, hydroxyl, (C 1 -C 4 )-alkoxy, oxo, amino, mono-(C 1 -C 4 )-alkylamino, di-(C 1 -C 4 )-alkylamino, hydroxycarbonyl and/or (C 1 -C 4 )-alkoxycarbonyl,

and

R 3 represents hydrogen,

and their salts, solvates and solvates of the salts.

2. The method of treatment of claim 1 , wherein the compound of formula (I) is 2-[5-(Hydroxymethyl)pyridin-2-yl]-4-[4-(trifluoromethyl)-1H-imidazol-1-yl]-1,2-dihydro-3H-pyrazol-3-one having the following formula

and its salts, solvates and solvates of the salts.