Compositions and methods with efficacy against spores and other organisms
View Patent ↗Compositions and methods for the disinfection of surfaces are provided. The compositions include at least about 40 weight percent of a C 1-6 alcohol, and a primary enhancer selected from protein denaturants. The disinfectant composition is characterized by a pH of less than about 3. Broad spectrum efficacy is achieved, and synergistic activity is exhibited against C. difficile spores.
1. A method for inactivation of C. difficile spores, the method comprising:
contacting the spores with an disinfectant composition comprising:
at least about 40 wt. % of a C 1-6 alcohol, and
a primary enhancer selected from the group consisting of protein denaturants,
wherein the disinfectant composition is characterized by a pH of less than about 3.
2. The method of claim 1 , wherein the disinfectant composition comprises at least about 50 wt. % of the C 1-6 alcohol, based upon the total weight of the disinfectant composition.
3. The method of claim 1 , wherein the primary enhancer is selected from the group consisting of amine-containing enhancers, α-aminoacids, salts of alkali metals, salts of alkaline earth metals, and anionic surfactants.
4. The method of claim 1 , wherein the amine-containing enhancer is selected from the group consisting of urea, dimethyl urea, thiourea, guanidine-HCl, guanidine thiocyanate, aminoguanidine bicarbonate, guanidine carbonate, guanidine phosphate, aminoguanidine-HCL, and mixtures thereof.
5. The method of claim 1 , wherein the primary enhancer is selected from the group consisting of sulfur-containing aminoacids and nitro-containing aminoacids.
6. The method of claim 1 , wherein the primary enhancer is selected from the group consisting of magnesium chloride, lithium perchlorate, and lithium acetate.
7. The method of claim 1 , wherein the primary enhancer is selected from the group consisting of anionic surfactants.
8. The method of claim 1 , wherein the enhancer is present in an amount of from about 0.1 to about 20 wt. %, based upon the total weight of the disinfectant composition.
9. The method of claim 1 , wherein the pH of the composition is less than about 2.75.
10. The method of claim 1 , wherein the composition further comprises a secondary enhancer selected from the group consisting of non-ionic surfactants, auxiliary antimicrobial agents, organic acids, and oxidizing agents.
11. A composition for the disinfection of surfaces, the composition comprising:
at least about 40 wt. % of a C 1-6 alcohol, based upon the total weight of the composition, and
a primary enhancer selected from the group consisting of protein denaturants, wherein the disinfectant composition is characterized by a pH of less than about 3, and wherein the composition exhibits a synergistically enhanced efficacy against bacterial and fungal spores, when compared to the efficacy of the alcohol or primary enhancer alone.
12. The composition of claim 11 , wherein the composition exhibits a synergistically enhanced efficacy against C. difficile spores, when compared to the efficacy of the alcohol or primary enhancer alone.
13. The composition of claim 11 , wherein the primary enhancer is selected from the group consisting of amine-containing enhancers, α-aminoacids, salts of alkali metals, salts of alkaline earth metals, and anionic surfactants.
14. The composition of claim 11 , wherein the amine-containing enhancer is selected from the group consisting of urea, thiourea, guanidine-HCl, guanidine thiocyanate, aminoguanidine bicarbonate, guanidine carbonate, guanidine phosphate, aminoguanidine-HCL, and mixtures thereof.
15. The composition of claim 11 , wherein the composition further comprises a secondary enhancer selected from the group consisting of non-ionic surfactants, auxiliary antimicrobial agents, organic acids, and oxidizing agents.
16. The composition of claim 11 , wherein the composition further comprises a secondary enhancer selected from the group consisting of decyl glucoside and polyalkoxylated dimethicones.
17. The composition of claim 11 , wherein the composition further comprises a secondary enhancer selected from the group consisting of citric acid, lauric acid, and tannic acid.
18. The composition of claim 11 , wherein the composition further comprises at least one auxiliary antimicrobial agent.
19. The composition of claim 11 , wherein the composition further comprises sodium nitrite.