Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase
View Patent ↗Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl dioctadecyl ammonium bromide (DDA). These formulations can be prepared by mixing an aqueous phase containing the antigen and adjuvant with an oil phase in the presence of an emulsifier.
1. A vaccine composition comprising an antigen component and an adjuvant component, wherein the adjuvant component comprises an oil-in-water emulsion, wherein further an aqueous phase of said oil-in-water emulsion comprises dimethyl dioctadecyl ammonium bromide (DDA) and an alkyl-polyacrylic acid (alkyl-PAA).
2. The vaccine composition of claim 1 , wherein said oil comprises at least one oil selected from the group consisting of a mineral oil, a terpene oil, soybean oil, olive oil, and a propylene glycol derivative.
3. The vaccine composition of claim 1 , wherein the adjuvant component further comprises at least one of CpG DNA, lipopolysaccharides, and monophosphoryl lipid A.
4. The vaccine composition of claim 3 , wherein the adjuvant component comprises CpG DNA and monophosphoryl lipid A.
5. The vaccine composition of claim 1 , wherein the composition further comprises one or more emulsifiers.
6. The vaccine composition of claim 1 , wherein the antigen is a poultry vaccine antigen.