Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of MPS IIIC
View Patent ↗Described herein are modified sugar, iminosugar and azasugar compounds and methods of making same. One or more of these modified compounds contain sulfates, sulfites, sulfamates and/or sulfonamides. Also described are pharmaceutical compositions/formulations comprising these compounds, as well as methods using these modified sugar compounds for the treatment of MPS IIIC (also known as Sanfilippo Type C).
1. A compound having a structure represented by formula III:
wherein: A 1 is acetyl;
R 1 is H, arylalkyl, aryl, or C 1-4 alkyl;
X and Y are each independently O or a lone pair of electrons; and
each Z is O; or
a pharmaceutically acceptable salt, or solvate thereof.
2. The compound of claim 1 , wherein the compound has a structure represented by formula IIIa:
or
or a pharmaceutically acceptable salt, or solvate thereof.
3. The compound of claim 1 , wherein the compound has a structure represented by formula IIIb:
or
or a pharmaceutically acceptable salt, or solvate thereof.
4. A compound have a structure represented by any of formulae (V)-(XI):
or
or a pharmaceutically acceptable salt, or solvate thereof.