Microfabricated nanopore device for sustained release of therapeutic agent
A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
1. A method for delivering a therapeutic agent, comprising:
providing a device comprising a capsule having a fluid impermeable wall defining a reservoir for containing a therapeutic agent; said capsule further comprising an exit port in communication with the reservoir and a nanopore membrane in communication with the exit port, said nanopore membrane comprising pores dimensioned to be between about 1 to about 5 times the Stoke's diameter of the therapeutic agent, to provide release kinetics which approach zero-order release of the therapeutic agent for a period of between about several weeks to about 6 months.
2. The method of claim 1 , further comprising forming an aqueous solution or suspension of said therapeutic agent in said reservoir prior to implantation of the device in a subject.
3. The method of claim 1 , wherein said providing comprises providing a device comprising a therapeutic agent disposed in the reservoir in dried form, and wherein an aqueous solution or suspension of said therapeutic agent in said reservoir is formed after implantation of the device into a subject.
4. The method of claim 1 , further comprising implanting the device subcutaneously.
5. The method of claim 1 , wherein the device is comprised of titanium.
6. The method of claim 1 , wherein said nanopore membrane comprises a microfabricated array of parallel channels, and wherein the smallest aspect of said channels is selected to provide a constant rate of release of said therapeutic agent.
7. The method of claim 1 , wherein said nanopore membrane comprises an array of parallel cylindrical pores.
8. The method of claim 1 , wherein the therapeutic agent is a peptide or a protein.
9. The method of claim 8 , wherein the therapeutic agent is a hormone agonist or a hormone antagonist.
10. The method of claim 8 , wherein the therapeutic agent is selected from the group consisting of interferon alpha, growth hormone and interferon beta.