IP Library › Patent Application 14621470
Patent Application
App. No. 14/621,470

ISOLATION OF ADULT MULTIPOTENTIAL CELLS BY TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE

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Quick Facts
Patent No.
US None
App. No.
14/621,470
Abstract

The present invention relates to the use of tissue non-specific alkaline phosphatase (TNAP) as a marker for identifying and/or isolating adult multipotential cells. The present invention also relates to cell populations enriched by methods of the present invention and therapeutic uses of these cells.

Claims (19)

1 . Use of TNAP as a marker for the identification and/or enrichment of adult multipotential cells.

2 - 17 . (canceled)

18 . An enriched population of adult multipotential cells obtained by a method according to claim 1 .

19 . An enriched population of TNAP+ adult multipotential cells.

20 . An expanded cell population obtained by culturing an enriched population of adult multipotential cells according to claim 18 .

21 - 24 . (canceled)

25 . A composition comprising a population of enriched adult multipotential cells according to claim 18 .

26 - 28 . (canceled)

29 . A method for generating or repairing tissue in a subject, the method comprising administering to the subject an enriched or expanded cell population according to claim 18 .

30 . A method for generating or repairing tissue in a subject, the method comprising administering to the subject a composition according to claim 25 .

31 . A method according to claim 29 wherein the tissue is bone, cardiac or cartilage tissue.

32 - 40 . (canceled)

41 . A STRO-3 hybridoma cell line deposited with ATCC on 19 Dec. 2005 under the provisions of the Budapest Treaty under deposit accession number PTA-7282.

42 . A STRO-3 antibody produced by the hybridoma cell line deposited with ATCC on 19 Dec. 2005 under the provisions of the Budapest Treaty under deposit accession number PTA-7282.

43 . An isolated antibody which binds to the same epitope on multipotential cells as the STRO-3 antibody produced by the hybridoma cell line deposited with ATCC on 19 Dec. 2005 under the provisions of the Budapest Treaty under deposit accession number PTA-7282.

44 . A composition comprising an antibody according to claim 42 or claim 43 .

45 . (canceled)

46 . A method for generating or repairing tissue in a subject, the method comprising administering to the subject an enriched or expanded cell population according to claim 19 .

47 . A method for generating or repairing tissue in a subject, the method comprising administering to the subject an enriched or expanded cell population according to claim 20 .