Multi-Purpose Bio-Material Composition
The present invention relates to a multi-purpose bio-material. One preferred embodiment of the present invention generally comprises KH 2 PO 4 , a metal oxide (i.e., MgO), a calcium-containing compound, a sugar and water. Exemplary calcium containing compounds include but are not limited to tri-calcium phosphates. The invented compositions has shown excellent adhesive properties as well as surprising and significant osteoproliferative properties.
1 . An osteoproliferative bio-material composition comprising KH 2 PO 4 in an amount between about 20-70 dry weight percent,
MgO in an amount between 10-50 dry weight percent,
a calcium containing compound, and
a sugar.
2 . The bio-material composition of claim 1 , further comprising water, wherein the bio-material composition is in the form of a slurry, wherein the bio-material has a controlled exothermic reaction under about 50° C. and sets in vivo.
3 . The bio-material composition of claim 2 , wherein the weight ratio of KH 2 PO 4 to MgO is between about 2:1 and 1:1.
4 . (canceled)
5 . (canceled)
6 . The bio-material composition as recited in claim 1 , wherein the calcium containing compound is Ca 10 (PO 4 ) 6 (OH) 2 .
7 . The bio-material composition as recited in claim 1 , wherein the calcium containing compound is selected from the group consisting of: α-Ca 3 (PO 4 ) 2 , β-Ca 3 (PO 4 ) 2 , Ca 10 (PO 4 ) 3 (OH) 2 , tetracalcium phosphate, amorphous calcium phosphate, bi-phasic calcium phosphate, poorly crystalline apatite, oxyapatite, octacalcium phosphate, dicalcium phosphate, dicalcium phosphate dihydrate, calcium metaphosphate, heptacalcium metaphosphate, calcium pyrophosphate and combinations thereof.
8 . The bio-material composition as recited in claim 1 , wherein the sugar is a disaccharide.
9 . The bio-material composition as recited in claim 1 , wherein the sugar is sucrose.
10 . (canceled)
11 . The bio-material composition of claim 1 , wherein:
the KH 2 PO 4 is present at between about 40 and 65 dry weight percent;
the MgO is present at between about 30 and 50 dry weight percent;
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugar is present at between 0.5 and 20 dry weight percent.
12 . The bio-material composition of claim 1 , wherein:
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugar is present at between 0.5 and 20 dry weight percent.
13 . (canceled)
14 . An osteoproliferative bio-material composition according to claim 1 , wherein the calcium containing compound is
a tri-calcium phosphate.
15 . The bio-material composition of claim 14 , wherein the weight ratio of KH 2 PO 4 to MgO is between about 2:1 and 1:1.
16 . (canceled)
17 . (canceled)
18 . (canceled)
19 . The bio-material composition of claim 14 , wherein the sugar is sucrose.
20 . (canceled)
21 . The bio-material composition of claim 14 , wherein the sugary compound is a disaccharide.
22 . The bio-material composition of claim 14 , wherein
the tri-calcium phosphate is present at between about 1 and 15 dry weight percent; and
the sugar is present at between 0.5 and 20 dry weight percent.
23 . The bio-material composition of claim 14 , wherein:
the KH 2 PO 4 is present at between about 40 and 65 dry weight percent;
the metal oxide is present at between about 30 and 50 dry weight percent;
the tri-calcium phosphate is present at between about 1 and 15 dry weight percent; and
the sugary compound is present at between 0.5 and 20 dry weight percent.
24 . The bio-material composition of claim 14 , wherein:
the KH 2 PO 4 is present at between about 40 and 50 dry weight percent;
the metal oxide is present at between about 35 and 50 dry weight percent;
the tri-calcium phosphate is present at between about 1 and 15 dry weight percent; and
the sugary compound is present at between 0.5 and 10 dry weight percent.
25 . The bio-material composition as recited in claim 14 , further comprising a sodium phosphate.
26 . An osteoproliferative bio-material composition comprising a dry phase consisting of the bio-material composition of claim 14 , and an aqueous phase.
27 . (canceled)
28 . A method for promoting hard tissue growth comprising applying a bio-material according to claim 3 to a tissue or hard tissue defect.
29 . (canceled)
30 . The method of claim 28 , wherein the hard tissue is bone.
31 . The method for promoting hard tissue growth according to claim 28 , wherein
the KH 2 PO 4 is present at between about 40 and 65 dry weight percent;
the MgO is present at between about 30 and 50 dry weight percent;
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugar is present at between 0.5 and 20 dry weight percent.
32 . The method for promoting hard tissue growth according to claim 28 comprising applying a bio-material to a tissue or hard tissue defect, wherein
the calcium containing compound is present at between about 1 and 15 dry weight percent; and
the sugar is present at between 0.5 and 20 dry weight percent.
33 . (canceled)
35 . A method for attaching an object to bone comprising affixing the object to the bone with the bio-material composition of claim 3 .
36 . The method of claim 35 , wherein the cementing is conducted without a fixation device.
37 . The method of claim 35 , wherein the cementing is conducted without application of growth factors.
38 . The method of claim 35 , wherein the object is an implant device.
39 . The method of claim 35 , wherein the object is bone, ligament, or tendon.
40 . A method for promoting bone growth comprising accessing a bone void and filling the bone void with a composition according to claim 3 .
41 . The method of claim 40 , wherein the filling is conducted without growth factor.
42 . The bio-material composition of claim 1 , wherein the bio-material composition is free of growth factors.
43 . The bio-material composition of claim 3 , wherein the bio-material composition is injectable through a syringe.
44 . The bio-material composition of claim 1 , wherein the slurry further comprises mono-sodium phosphate.
45 . The bio-material composition of claim 3 , wherein the composition exhibits micro and macro pores once set.
46 . A method of making an osteoproliferative bio-material composition comprising mixing,
KH 2 PO 4 in an amount between about 20-70 dry weight percent;
MgO in an amount between 10-50 dry weight percent;
a calcium containing compound; and
a sugar,
wherein the composition undergoes a controlled exothermic reaction under about 50° C. and sets in vivo.