Transdermal drug delivery system containing donepezil
Certain embodiments of the invention relates to a transdermal drug delivery system containing donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, more specifically to a transdermal drug delivery system containing a drug-containing matrix layer comprising donepezil or its pharmaceutically acceptable salt, a styrene copolymer, a hydrogenated rosin glycerol ester, and optionally a hydrocarbon resin.
1. A transdermal drug delivery system comprising:
a drug containing matrix layer consisting of:
7-15% by weight of donepezil or a pharmaceutically acceptable salt thereof based on a total weight of the drug-containing matrix layer;
33-55% by weight of a styrene copolymer based on a total weight of the drug-containing matrix layer; and
8-38% by weight of a hydrocarbon resin and a hydrogenated rosin glycerol ester based on a total weight of the drug-containing matrix layer.
2. The transdermal drug delivery system of claim 1 , wherein the styrene copolymer is one or more selected from the group consisting of styrene-butadiene-styrene copolymer, styrene-isoprene-styrene copolymer, styrene-ethylene/butylene-styrene copolymer and styrene-ethylene/propylene-styrene copolymer.
3. The transdermal drug delivery system of claim 1 , wherein weight ratio of the hydrogenated rosin glycerol esters to hydrocarbon resin is from 1:1 to 1:4.
4. The transdermal drug delivery system of claim 1 , wherein the hydrocarbon resin is selected from the group consisting of cyclic, acyclic, or aromatic hydrocarbon resin.
5. The transdermal drug delivery system of claim 1 , wherein the hydrocarbon resin is selected from the group consisting of C 5-9 acyclic hydrocarbon resin, C 5-9 cyclic hydrocarbon resin.
6. A transdermal drug delivery system consisting of a backing layer, a drug-containing matrix layer, and a release layer,
wherein the drug containing matrix layer consists of:
7-15% by weight of donepezil or a pharmaceutically acceptable salt thereof based on a total weight of the drug-containing matrix layer;
33-55% by weight of a styrene copolymer based on a total weight of the drug-containing matrix layer; and
8-38% by weight of a hydrocarbon resin and a hydrogenated rosin glycerol ester based on a total weight of the drug-containing matrix layer.
7. A transdermal drug delivery system comprising:
a drug containing matrix layer consisting of:
donepezil or a pharmaceutically acceptable salt thereof;
a styrene copolymer;
a hydrocarbon resin;
a hydrogenated rosin glycerol ester;
and a plasticizer.