METHODS OF ADMINISTERING RIFAXIMIN FOR WEIGHT LOSS AND TREATMENT OF OBESITY
Methods of reducing weight in a subject are provided, wherein the methods comprise administering a composition comprising an effective amount of rifaximin to a subject in need of treatment for weight loss. In some embodiments, the subject is considered obese (BMI>30).
1 . A method of producing weight loss in a subject, comprising administering a composition comprising rifaximin to a subject in need thereof.
2 . The method of claim 1 , wherein administration of the composition results in at least about a 2% reduction in the weight of the subject.
3 . The method of claim 1 , wherein the administration of the composition results in at least about a 5% reduction in the weight of the subject.
4 . The method of claim 1 , wherein the administration of the composition results in at least about a 10% reduction in the weight of the subject.
5 . The method of claim 1 , wherein the subject is administered rifaximin at a dose of about 50 mg to about 6000 mg per day.
6 . The method of claim 1 , wherein the subject is administered rifaximin at a dose of between about 100 mg and about 6000 mg; from between about 50 mg and about 2500 mg BID; from between about 50 mg and about 2000 mg TID; 200 mg TID; 200 mg BID or 200 mg QD.
7 . The method of claim 1 , wherein the subject is administered rifaximin at a dose of about 550 mg, 600 mg or 1650 mg TID, QD or BID.
8 . The method of claim 1 , wherein the subject is administered rifaximin at a dose of about 550 mg BID.
9 . The method of claim 1 , wherein the subject is administered the composition for between about 1 week and about 24 months.
10 . The method of claim 1 , wherein the subject is administered the composition for about 20 days.
11 . The method of claim 1 , wherein the subject has a body mass index (BMI) of greater than about 30.
12 . The method of claim 1 , wherein the subject is also suffering from at least one of: GERD, hypertension, diabetes, and a lipid disorder.
13 . A method of reducing body weight comprising:
identifying a subject in need of reduced body weight;
administering a composition comprising rifaximin to the subject, and reducing the subject's body weight by at least 2%.
14 . A method of treating obesity comprising:
identifying a subject in need of treatment for obesity;
administering a composition comprising rifaximin to the subject, and reducing the subject's body weight by at least 2%.
15 . The method of claim 13 , wherein the subject's body weight is reduced by at least 5% or 10%.
16 . The method of claim 13 , wherein the subject in need of treatment has a BMI of at least 30, 35, or 40.
17 . The method of claim 13 , wherein the subject is administered rifaximin at a dose of about 50 mg to about 6000 mg per day.
18 . The method of claim 13 , wherein the subject is administered rifaximin at a dose of about 100 mg to about 6000 mg; from about 50 mg to about 2500 mg BID; from about 50 mg to about 2000 mg TID; 200 mg TID; 200 mg BID or 200 mg QD.
19 . The method of claim 13 , wherein the subject is administered rifaximin at a dose of about 550 mg, 600 mg or 1650 mg TID, QD or BID.
20 . The method of claim 13 , wherein the subject is administered rifaximin at a dose of about 550 mg BID.
21 . The method of claim 13 , wherein the subject is administered the composition for between about 1 week and about 24 months.
22 . The method of claim 13 , wherein the subject is administered the composition for about 20 days.
23 . The method of claim 1 , wherein the subject is on a sugar-restricted diet.
24 . The method of claim 23 , wherein the subject's intake of free sugars is less than about 10% of the total energy intake.
25 . The method of claim 24 , wherein the subject's intake of free sugars is less than about 5% of the total energy intake.