TREATMENT OF LEG ULCERS USING PLACENTA DERIVED COLLAGEN BIOFABRIC
The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.
1 .- 24 . (canceled)
25 . A sterilized, decellularized, and dehydrated amnion-derived biofabric, wherein said biofabric comprises vascular-endothelial growth factor (VEGF) and fibroblast growth factor (FGF).
26 . The biofabric of claim 25 , comprising collagen, fibronectin, and proteoglycans.
27 . A pharmaceutical composition comprising the biofabric of claim 25 .
28 . A pharmaceutical composition comprising the biofabric of claim 26 .
29 . The biofabric of claim 25 , wherein said biofabric is shaped as a sheet or membrane.
30 . The biofabric of claim 29 , wherein said biofabric is shaped as a sheet.
31 . The biofabric of claim 25 , wherein said biofabric is shaped as a netting or webbing.
32 . The biofabric of claim 25 , wherein said biofabric is mounted on a support.
33 . The biofabric of claim 32 , wherein said support is a bandage.