Apparatus and process for encapsulating capsules or other solid dosage forms within capsules
The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
1. A dispensing and feeding device for dispensing and feeding solid dosage forms into a softgel capsule, said dispensing and feeding device including a hopper having said solid dosage forms, channelguides for transporting said solid dosage forms, and a grasping claw for dispensing said solid dosage forms, each grasping claw having volume capacity for grasping a fixed dose of the solid dosage forms coming through one of the said channelguide and configured for releasing the fixed dose into a pocket of the softgel.
2. A method for making softgel capsules having incorporated therein other solid dosage forms, said method comprising:
(a) casting a gel-forming composition to make films;
(b) passing said films through a pair of rotary dies having vacuum means to make pockets of a softgel capsule;
(c) feeding via channelguides smaller solid dosage forms into said pockets using a lateral dispensing and feeding system that uses grasping claws, each grasping claw having volume capacity for grasping a fixed dose of the solid dosage forms coming through one of said channelguides and configured for releasing the fixed dose into a pocket of the softgel capsule;
(d) filling said pockets with a medicine formulation in liquid form via a wedge segment; and
(e) forming said softgel capsule by sealing the pockets together.
3. A process for making a softgel capsule having incorporated therein one or more smaller capsules, said method comprising:
(a) feeding film sheets between a first die roll and a second die roll wherein each of the die rolls have capsule pockets in a plurality of rows and said capsule pockets have at least one orifice for application of suction;
(b) applying suction while said film sheets are in place in the capsule pockets;
(c) feeding preformed one or more smaller capsules onto the film sheets overlying the die rolls at positions having the capsule pockets via channelguides through a lateral dispensing device having a hopper and grasping claws, each grasping claw having volume capacity for grasping a fixed dose of the preformed smaller capsule coming through one of said channelguides and configured for releasing the fixed dose into a capsule pocket;
(d) filling said capsule pockets also via a wedge segment with a liquid medical formulation; and
(e) cutting the film sheets about the capsule pockets to form said softgel capsules having the one or more smaller capsules in combination with the liquid medical formulation.