Osteoclast inhibitors such as zoledronic acid for low back pain treatment
View Patent ↗Methods for the safe administration of imidazole or imidazolium compounds, and conditions that may be treated by these methods, are described herein.
1. A method of treating Modic changes type I, comprising administering an osteoclast inhibitor to a mammal in need thereof, wherein the mammal experiences pain relief three months after the osteoclast inhibitor is administered; and
wherein the osteoclast inhibitor is risedronic acid, cimadronic acid, or etidronic acid.
2. The method of claim 1 , wherein the osteoclast inhibitor is administered orally.
3. The method of claim 1 , wherein the Modic change is located at C1/2, C2/3, C3/4, C4/5, C5/6, or C6/7.
4. The method of claim 1 , wherein the Modic change is located at C7/T1, T1/2, T2/3, T3/4, T4/5, T5/6, T6/7, T7/8, T8/9, T9/10, T10/11, or T11/12.
5. The method of claim 1 , wherein the Modic change is located at T12/L1, L1/2, L2/3, L3/4, L4/5, or L5/S1.
6. The method of claim 1 , wherein the osteoclast inhibitor is administered weekly.
7. The method of claim 1 , wherein the osteoclast inhibitor is administered weekly for 1 or 2 months.
8. The method of claim 1 , wherein the osteoclast inhibitor is administered once a month or less frequently.
9. The method of claim 1 , wherein the osteoclast inhibitor is administered 2 to 5 times in a month.
10. The method of claim 1 , wherein the osteoclast inhibitor is administered daily.
11. The method of claim 10 , wherein the osteoclast inhibitor is orally administered for 5 to 10 consecutive days.