IP Library › Granted Patent US 9,149,539
Granted Patent B1
US 9,149,539 · App. 14/645,347 · Granted Oct 6, 2015

Crystalline naloxol-PEG conjugate

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Quick Facts
Patent No.
US 9,149,539
App. No.
14/645,347
Granted
Oct 6, 2015
Kind
B1
Abstract

Naloxol-polyethylene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.

Claims (1)

1. A crystalline phosphate salt of mPEG7-O-naloxol having XRPD d values of (Å) comprising 21.0; 12.1; 7.9; 6.5; 5.3; 4.83; 4.24; 3.81; and 3.75.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Jul 19, 2024
From: HCR REDHILL SPV, LLC
To: REDHILL BIOPHARMA INC.; REDHILL BIOPHARMA LTD.
Reel/Frame 068034/0458 →
SECURITY INTEREST Recorded Jul 10, 2024
From: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
To: HCR REDHILL SPV, LLC, AS SUCCESSOR ADMINISTRATIVE AGENT
Reel/Frame 067953/0105 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2020
From: LECHUGA-BALLESTEROS, DAVID
To: NEKTAR THERAPEUTICS
Reel/Frame 053557/0568 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
SECURITY INTEREST Recorded Feb 24, 2020
From: REDHILL BIOPHARMA INC.
To: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 051909/0460 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →