IP Library Granted Patent US 10,087,172
Granted Patent B2
US 10,087,172 · App. 14/646,634 · Granted Oct 2, 2018

Compounds and their methods of use

Inventors: Rene M. Lemieux (Charlestown, MA); Janeta Popovici-Muller (Windham, NH); Francesco G. Salituro (Marlborough, MA); Jeffrey O. Saunders (Lincoln, MA); Jeremy Travins (Southborough, MA); Yongsheng Chen (Shanghai, CN)
Assignee: AGIOS PHARMACEUTICALS, INC.
C07D417/14C07D285/135
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Quick Facts
Patent No.
US 10,087,172
App. No.
14/646,634
Granted
Oct 2, 2018
Kind
B2
Abstract

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

Claims (11)

1. A compound or a pharmaceutically acceptable salt thereof, which is

2. A compound or a pharmaceutically acceptable salt thereof, which is

3. A compound or a pharmaceutically acceptable salt thereof, which is

4. A compound or a pharmaceutically acceptable salt thereof, which is

5. A compound or a pharmaceutically acceptable salt thereof, which is

6. A compound or a pharmaceutically acceptable salt thereof, which is

7. A compound or a pharmaceutically acceptable salt thereof, which is

8. A compound or a pharmaceutically acceptable salt thereof, which is

9. A compound or a pharmaceutically acceptable salt thereof, which is

10. A compound or a pharmaceutically acceptable salt thereof, which is

11. A compound or a pharmaceutically acceptable salt thereof, which is

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME SERVIER PHARMACEUTICALS LLC BY REMOVAL OF COMMA AND UPDATING ZIP CODE TO 02210 PREVIOUSLY RECORDED ON REEL 056224 FRAME 0921. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECTIVE ASSIGNMENT. Recorded Oct 28, 2021
From: AGIOS PHARMACEUTICALS, INC.
To: SERVIER PHARMACEUTICALS LLC
Reel/Frame 057970/0314 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NO. 10,172,864 TO THE CORRECT APP NO. 61/160,253 PREVIOUSLY RECORDED ON REEL 056179 FRAME 0417. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 12, 2021
From: AGIOS PHARMACEUTICALS, INC.
To: SERVIER PHARMACEUTICALS, LLC
Reel/Frame 056224/0921 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 7, 2021
From: AGIOS PHARMACEUTICALS, INC.
To: SERVIER PHARMACEUTICALS, LLC
Reel/Frame 056179/0417 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2016
From: LEMIEUX, RENE M.; POPOVICI-MULLER, JANETA; SALITURO, FRANCESCO G.; SAUNDERS, JEFFREY O.; TRAVINS, JEREMY
To: AGIOS PHARMACEUTICALS, INC.
Reel/Frame 039460/0012 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2016
From: SHANGHAI CHEMPARTNER CO., LTD.
To: AGIOS PHARMACEUTICALS, INC.
Reel/Frame 039460/0021 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2016
From: CHEN, YONGSHENG
To: SHANGHAI CHEMPARTNER CO., LTD.
Reel/Frame 039707/0341 →
Priority Claims (2)
WO PCT/CN2012/085023 · Nov 22, 2012 · international
WO PCT/CN2013/000294 · Mar 15, 2013 · international
Continuity (1)
Related Publication 20150291576A1 · Oct 15, 2015