Vaccine to protect a ruminant against pneumonia caused by pasteurella multocida
The present invention pertains to a vaccine comprising live attenuated Pasteurella multocida bacteria for protection of a ruminant against pneumonia caused by P. multocida by administration of the vaccine to the upper respiratory tract of the ruminant via intranasal atomization of the vaccine. The invention also pertains to a method to use the vaccine to protect a ruminant against pneumonia caused by P. multocida bacteria.
1. A method to protect a ruminant against pneumonia caused by Pasteurella multocida bacteria, comprising administering by intranasal atomization a vaccine comprising live attenuated P. multocida bacteria to the upper respiratory tract of the ruminant.
2. The method of claim 1 wherein the intranasal atomization provides a mist of vaccine particles having an average size below 50 μm in diameter.
3. The method of claim 2 wherein the average particle size is between 20 and 40 μm in diameter.
4. The method of claim 3 wherein the vaccine additionally comprises live attenuated parainfluenza-3 virus and live attenuated bovine respiratory syncytial virus for protection against respiratory disease caused by parainfluenza virus and bovine respiratory syncytial virus.
5. The method of claim 4 wherein the vaccine further comprises live attenuated infectious bovine rhinotracheitis virus for protection against respiratory disease caused by infectious bovine rhinotracheitis virus.
6. The method of claim 2 wherein the vaccine additionally comprises live attenuated parainfluenza-3 virus and live attenuated bovine respiratory syncytial virus for protection against respiratory disease caused by parainfluenza virus and bovine respiratory syncytial virus.
7. The method of claim 6 wherein the vaccine further comprises live attenuated infectious bovine rhinotracheitis virus for protection against respiratory disease caused by infectious bovine rhinotracheitis virus.
8. The method of claim 1 wherein the vaccine additionally comprises live attenuated parainfluenza-3 virus and live attenuated bovine respiratory syncytial virus for protection against respiratory disease caused by parainfluenza virus and bovine respiratory syncytial virus.
9. The method of claim 8 wherein the vaccine further comprises live attenuated infectious bovine rhinotracheitis virus for protection against respiratory disease caused by infectious bovine rhinotracheitis virus.