Room temperature curable siloxane-based gels

1. A gel composition comprising the reaction product of a condensation curable mixture comprising:

at least 0.5 to less than 45% by weight silicone resin comprising at least two hydroxyl groups;

at least 55 to less than 99.5% by weight of at least one silanol-terminated siloxane fluid; and

a co-curable compound comprising an amino group, wherein the condensation curable mixture is curable at room temperature and wherein the condensation curable mixture upon curing is a gel selected from a medical gel adhesive or a medical gel sealant, wherein the gel comprises a crosslinked matrix containing a liquid or fluid.

2. The gel composition of claim 1 , wherein the co-curable compound comprising an amino group has the general structure:

R 6 2-x R 7 x N-G-Si(OR 8 ) y R 9 3-y

wherein each R 6 and R 7 independently comprises a hydrogen atom or an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

x is an integer of 0, 1, or 2;

G is a divalent linking group;

each R 8 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

each R 9 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group; and

y is an integer of 1, 2, or 3.

3. The gel composition of claim 2 , wherein G is a divalent alkylene group having the general structure:

(—CH 2 -) a

wherein a is an integer of 1 to 18.

4. The gel composition of claim 1 , further comprising at least one non-reactive siloxane fluid.

5. The gel composition of claim 1 , wherein the gel composition comprises a medical gel sealant.

6. The gel composition of claim 1 , wherein the gel composition comprises a medical gel adhesive layer.

7. The gel composition of claim 1 , wherein the gel composition comprises at least 0.5% by weight of extractable siloxane fluid.

8. An article comprising:

a substrate; and

a layer of adhesive gel disposed on at least a portion of at least one major surface of the substrate, the adhesive gel comprising the reaction product of a condensation curable mixture comprising:

at least 0.5 to less than 45% by weight silicone resin comprising at least two hydroxyl groups;

at least 55 to less than 99.5% by weight of at least one silanol-terminated siloxane fluid; and

a co-curable compound comprising an amino group, wherein the condensation curable mixture is curable at room temperature, and wherein the gel comprises a crosslinked matrix and a liquid or fluid.

9. The article of claim 8 , wherein the co-curable compound comprising an amino group has the general structure:

R 6 2-x R 7 x N-G-Si(OR 8 ) y R 9 3-y

wherein each R 6 and R 7 independently comprises a hydrogen atom or an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

x is an integer of 0, 1, or 2;

G is a divalent linking group;

each R 8 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

each R 9 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group; and

y is an integer of 1, 2, or 3.

10. The article of claim 9 , wherein G is a divalent alkylene group having the general structure:

(—CH 2 —) a

wherein a is an integer of 1 to 18.

11. The article of claim 8 , wherein the adhesive gel further comprises at least one non-reactive siloxane fluid.

12. The article of claim 8 , wherein the substrate comprises a release liner or a medical substrate.

13. The article of claim 8 , wherein the reaction product of the condensation curable mixture has been exposed to ultra-violet radiation, gamma radiation, or an electron beam.

14. A method of preparing a medical article comprising:

providing a condensation curable gel precursor composition comprising:

at least 0.5 to less than 45% by weight silicone resin comprising at least two hydroxyl groups;

at least 55 to less than 99.5% by weight of at least one silanol-terminated siloxane fluid; and

a co-curable compound comprising an amino group, wherein the condensation curable gel precursor composition is curable at room temperature;

applying the condensation curable gel precursor composition to a substrate; and

permitting the condensation curable gel precursor composition to cure at room temperature to form a gel.

15. The method of claim 14 , wherein providing the condensation curable gel precursor composition comprises mixing together of a 2 part mixture, the 2 part mixture comprising:

1) the at least 0.5 to less than 45% by weight silicone resin comprising at least two hydroxyl groups the; at least 55 to less than 99.5% by weight of at least one silanol-terminated siloxane fluid; and

2) the co-curable compound comprising an amino group, wherein 1) and 2) are physically isolated from each other prior to mixing.

16. The method of claim 15 , wherein the gel comprises a sealant.

17. The method of claim 14 , wherein the gel comprises an adhesive.

18. The method of claim 17 , wherein the substrate comprises a release liner or a medical substrate.

19. The method of claim 18 , wherein the substrate comprises a release liner, and the method further comprises laminating the gel to a second substrate or to a surface.

20. The method of claim 14 , wherein the co-curable compound comprising an amino group has the general structure:

R 6 2-x R 7 x N-G-Si(OR 8 ) y R 9 3-y

wherein each R 6 and R 7 independently comprises a hydrogen atom or an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

x is an integer of 0, 1, or 2;

G is a divalent linking group;

each R 8 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group;

each R 9 independently is an alkyl, aryl, heteroalkyl, heteroaryl, or aralkyl group; and

y is an integer of 1, 2, or 3.

21. The method of claim 14 , wherein the gel further comprises at least one non-reactive siloxane fluid.

22. The method of claim 14 , further comprising exposing the condensation curable gel precursor composition to ultra-violet radiation, gamma radiation, or an electron beam.