PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES
The present invention relates to PPARy-sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder including Huntington's disease, epilepsy, AMS, and MS.
1 . A method for treating, reducing the symptoms of, or delaying the onset of a neurodegenerative disease selected from Huntington's disease, ALS, MS, or epilepsy comprising administering to a patient in need thereof a compound having the structure:
or a pharmaceutically acceptable salt thereof.
2 . (canceled)
3 . The method of claim 1 , wherein the neurodegenerative disease is Huntington's disease.
4 . The method of claim 3 , further comprising administering to the patient tetrabenazine, haloperidol, clozapine, clonazepam, diazepam, escitalopram, fluoxetine, sertraline, or any combination thereof.
5 . The method of claim 1 , wherein the neurodegenerative disease is epilepsy.
6 . The method of claim 5 , further comprising administering an anti-convulsive medication.
7 . The method of claim 6 , wherein the anti-convulsive medication is selected from: carbamazepine (Tegretol™), clorazepate (Tranxene™), clonazepam (Klonopin™), ethosuximide (Zarontin™), felbamate (Felbatol™), fosphenytoin (Cerebyx™), gabapentin (Neurontin™), lacosamide (Vimpat™), lamotrigine (Lamictal™), levetiracetam (Keppra™), oxcarbazepine (Trileptal™), phenobarbital (Luminal™), phenytoin (Dilantin™), pregabalin (Lyrica™), primidone (Mysoline™), tiagabine (Gabitril™), topiramate (Topamax™), valproate semisodium (Depakote™), valproic acid (Depakene™), zonisamide (Zonegran™), or any combination thereof.
8 . The method of claim 5 , further comprising administering diazepam (Valium™, Diastat™) and lorazepam (Ativan™), paraldehyde (Paral™), midazolam (Versed™), pentobarbital (Nembutal™), acetazolamide (Diamox), progesterone, adrenocorticotropic hormone (ACTH, Acthar™), prednisone, bromide, or any combination thereof.
9 . The method of claim 1 , further comprising administering LDOPA to the patient.
10 . (canceled)
11 . The method of claim 1 , wherein the compound is administered as a potassium or sodium salt.
12 . (canceled)
13 . The method of claim 11 , wherein the neurodegenerative disease is Huntington's disease.
14 . The method of claim 13 , further comprising administering to the patient tetrabenazine, haloperidol, clozapine, clonazepam, diazepam, escitalopram, fluoxetine, sertraline, or any combination thereof.
15 . The method of claim 11 , wherein the neurodegenerative disease is epilepsy.
16 . The method of claim 15 , further comprising administering an anti-convulsive medication.
17 . The method of claim 16 , wherein the anti-convulsive medication is selected from: carbamazepine (Tegretol™), clorazepate (Tranxene™), clonazepam (Klonopin™), ethosuximide (Zarontin™), felbamate (Felbatol™), fosphenytoin (Cerebyx™), gabapentin (Neurontin™), lacosamide (Vimpat™), lamotrigine (Lamictal™), levetiracetam (Keppra™), oxcarbazepine (Trileptal™), phenobarbital (Luminal™), phenytoin (Dilantin™), pregabalin (Lyrica™), primidone (Mysoline™), tiagabine (Gabitril™), topiramate (Topamax™), valproate semisodium (Depakote™), valproic acid (Depakene™), zonisamide (Zonegran™), or any combination thereof.
18 . The method of claim 15 , further comprising administering diazepam (Valium™, Diastat™) and lorazepam (Ativan™), paraldehyde (Paral™), midazolam (Versed™), pentobarbital (Nembutal™), acetazolamide (Diamox), progesterone, adrenocorticotropic hormone (ACTH, Acthar™), prednisone, bromide, or any combination thereof.
19 . The method of claim 11 , further comprising administering LDOPA to the patient.