Adhesive assemblies and microneedle injection apparatuses comprising same
Adhesive assemblies and microneedle injection apparatuses comprising same. The apparatus ( 100 ) can include a housing ( 102 ) having a base and an opening ( 115 ) formed in the base; and an applicator comprising a microneedle array ( 104 ), the microneedle array comprising a first major surface ( 111 ) and microneedles ( 105 ). The applicator can be movable between a first position, and a second position in which at least a portion of the microneedle array extends through the opening in the base. The apparatus can further include an adhesive assembly ( 118 ), which can be adhered to the base of the housing. The adhesive assembly can include an extension ( 125 ) that extends at least partially into the area defined by the opening, such that when the applicator is in the second position, at least a portion of the first major surface of the microneedle array is in contact with the extension of the adhesive assembly.
1. A microneedle injection apparatus comprising:
a housing having a base and an opening in the base, the opening in the base defining an area;
an applicator comprising a microneedle array, the microneedle array comprising a first major surface and a plurality of microneedles that protrude from the first major surface, the applicator movable between
a first position in which the microneedle array is recessed within the housing such that the microneedle array does not extend beyond the base of the housing, and
a second position in which at least a portion of the microneedle array extends through the opening in the base and beyond the base of the housing; and
an adhesive assembly adhered to the base, the adhesive assembly including a plurality of adhesive extensions that extend at least partially into the area defined by the opening in the base, such that when the applicator is in the second position, at least a portion of a first major surface of the microneedle array is in contact with at least a portion of each of the plurality of adhesive extensions of the adhesive assembly, wherein
the adhesive assembly includes a first side positioned toward the base and a second side opposite the first side, and further wherein
each of the plurality of adhesive extensions of the adhesive assembly include adhesive on a first side and a second side wherein the second side of each of the plurality of adhesive extensions is the second side of the adhesive assembly and further wherein the first side of each of the plurality of adhesive extensions is configured to adhere to the first major surface of the microneedle array and the second side of each of the plurality of adhesive extensions is configured to adhere to skin, when the applicator is in the second position, and further wherein the plurality of adhesive extensions are separated by vents and arranged to define an opening in the adhesive assembly.
2. The apparatus of claim 1 , wherein the plurality of adhesive extensions extend only partially into the area defined by the opening in the base.
3. The apparatus of claim 1 , the opening in the adhesive assembly is in a form of an annulus, the annulus being sized to contain the plurality of microneedles.
4. The apparatus of claim 1 , wherein the first side of the adhesive assembly is configured to adhere to the base, and the second side of the adhesive assembly is configured to adhere to a surface of the skin.
5. The apparatus of claim 1 , wherein the adhesive assembly comprises:
a first layer configured to be coupled to the base and including, and
a second layer comprising the plurality of adhesive extensions.
6. The apparatus of claim 5 , wherein the first layer includes a shock-absorbing layer.
7. The apparatus of claim 5 , wherein the first layer includes the first side of the adhesive assembly that is configured to be coupled to the base and a second side opposite the first side, and wherein the second layer includes at least one layer of adhesive.
8. The apparatus of claim 7 , wherein the first side of the first layer of the adhesive assembly includes an adhesive of the adhesive assembly that is configured to adhere the first side of the first layer to the base.
9. The apparatus of claim 7 , wherein the second layer of adhesive assembly includes a first adhesive layer and a second adhesive layer, wherein the first adhesive layer is configured to adhere to the second side of the first layer and the first major surface of the microneedle array, and wherein the second adhesive layer comprises a skin-contact adhesive.
10. The apparatus of claim 9 , wherein the plurality of adhesive extensions are formed by the first adhesive layer and the second adhesive layer of the second layer.
11. The apparatus of claim 1 , wherein the plurality of adhesive extensions are discontinuous about a periphery of the opening in the base to define vents.
12. The apparatus of claim 1 , wherein the plurality of adhesive extensions extend from a location adjacent a periphery of the opening in the base to at least partially into the opening in the base.
13. The apparatus of claim 1 , wherein the first major surface of the microneedle array contacts the adhesive assembly when the applicator is moved to the second position.
14. The apparatus of claim 1 , wherein the applicator is configured to be moved from the first position to the second position at a velocity of about 2 m/s to about 20 m/s.
15. The apparatus of claim 1 , wherein the plurality of adhesive extensions are positioned such that at least a portion of the microneedle array strikes and adheres to at least a portion of the plurality of adhesive extensions while the microneedle array is traveling from the first position to the second position.
16. The apparatus of claim 1 , wherein the plurality of extensions are discontinuous and the plurality of vents extend outwardly from the opening of the adhesive assembly.