IP Library › Patent Application 14657557
Patent Application
App. No. 14/657,557

METHOD OF PREPARING POROUS CARBONATE APATITE FROM NATURAL BONE

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Quick Facts
Patent No.
US None
App. No.
14/657,557
Abstract

A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m 2 /g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.

Claims (26)

1 . A carbonate apatite prepared from natural bone, the carbonate apatite having a surface area of 15 to 70 m 2 /g and a protein content of 2000-8000 parts per million.

2 . The carbonate apatite of claim 1 , wherein the carbonate apatite has a carbonate content of 1 to 7%.

3 . The carbonate apatite of claim 2 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%.

4 . The carbonate apatite of claim 1 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%.

5 . A carbonate apatite prepared from natural bone by the steps consisting of:

providing cancellous bone particles;

treating the bone particles with hot water and an organic solvent;

repeating the treating step at least once;

drying the treated bone particles; and

heating the treated dried bone particles at 500° C. to 620° C. for 10 to 50 hours,

wherein the carbonate apatite has a protein content of 2000-8000 parts per million.

6 . The carbonate apatite of claim 5 , wherein the carbonate apatite has a surface area of 15 to 70 m 2 /g.

7 . The carbonate apatite of claim 6 , wherein the carbonate apatite has a carbonate content of 1 to 7%.

8 . The carbonate apatite of claim 7 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%.

9 . The carbonate apatite of claim 5 , wherein the carbonate apatite has a carbonate content of 1 to 7%.

10 . The carbonate apatite of claim 9 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%.

11 . The carbonate apatite of claim 5 , wherein the carbonate apatite has a degree of crystallinity of 45 to 65%.

12 . The carbonate apatite of claim 11 , wherein the carbonate apatite has a surface area of 15 to 70 m 2 /g.

13 . The method of claim 5 , wherein the organic solvent is isopropanol.

14 . The method of claim 6 , wherein the organic solvent is isopropanol.

15 . The method of claim 5 , wherein the temperature of the hot water is 80° C. to 100° C.

16 . The method of claim 6 , wherein the temperature of the hot water is 80° C. to 100° C.

17 . The method of claim 7 , wherein the organic solvent is isopropanol.

18 . The method of claim 8 , wherein the organic solvent is isopropanol.

19 . The method of claim 7 , wherein the temperature of the hot water is 80° C. to 100° C.

20 . The method of claim 8 , wherein the temperature of the hot water is 80° C. to 100° C.