Modular chemiresistive sensor
The present invention relates to a modular chemiresistive sensor. In particular, a modular chemiresistive sensor for hypergolic fuel and oxidizer leak detection, carbon dioxide monitoring and detection of disease biomarkers. The sensor preferably has two gold or platinum electrodes mounted on a silicon substrate where the electrodes are connected to a power source and are separated by a gap of 0.5 to 4.0 μM. A polymer nanowire or carbon nanotube spans the gap between the electrodes and connects the electrodes electrically. The electrodes are further connected to a circuit board having a processor and data storage, where the processor can measure current and voltage values between the electrodes and compare the current and voltage values with current and voltage values stored in the data storage and assigned to particular concentrations of a pre-determined substance such as those listed above or a variety of other substances.
1. A modular chemiresistive sensor system comprising at least two noble metal electrodes, a power source and a circuit board for measuring current and/or voltage between the at least two noble metal electrodes, the at least two noble metal electrodes mounted on a silicon substrate and separated by a gap of 0.5 to 4.0 μm; and
a polymer nanowire, said polymer nanowire having a porous nano-network, spanning the gap and connecting the at least two noble metal electrodes
said system including a processor configured to display the measured current and/or voltage between the at least two noble metal electrodes as a concentration of a compound selected for detection.
2. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire has a diameter less than 150 nm.
3. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire comprises at least one of the following: aniline, pyrrole, thiophene or ethylenedioxythiophene.
4. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire comprises at least one of the following: amine functionalized 2-(2-aminoethyl) aniline, amine functionalized pyrrole, thiophene or ethylenedioxythiophene.
5. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire comprises covalently attached antibodies specific to Alzheimer's disease biomarkers.
6. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire comprises covalently attached antibodies specific to various cancer biomarkers.
7. The modular chemiresistive sensor system of claim 1 where the polymer nanowire comprises anti-Aβ peptide antibodies.
8. The modular chemiresistive sensor system of claim 5 where the antibodies are attached to the porous polymer nanowire via amide coupling with N-hydroxysuccinimide.
9. The modular chemiresistive sensor system of claim 1 where the porous polymer nanowire comprises anti-PSA antibodies.
10. A modular chemiresistive sensor comprising at least two noble metal electrodes, a power source and a circuit board, said at least two noble metal electrodes mounted on a silicon substrate and separated by a gap of 0.5 to 4.0 μm;
a porous polymer nanowire spanning the gap and connecting the at least two noble metal electrodes;
where the circuit board comprises a processor and data storage, said processor configured to measure current and voltage values between the at least two noble metal electrodes and compare the current and voltage values with current and voltage values stored in the data storage, said current and voltage values indicating particular concentrations of a pre-determined substance.
11. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of nitrogen dioxide.
12. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of monomethyl hydrazine.
13. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of Alzheimer's disease biomarker.
14. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of Aβ peptides.
15. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of prostate specific antigen.
16. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is functionalized to selectively determine the presence of carbon dioxide.
17. The modular chemiresistive sensor system of claim 10 where the porous polymer nanowire is selected from the group consisting of polyacetylene, polypyrrole, poly(3,4-ethylenedioxythiophene), polyaniline, poly(o-methoxyaniline), poly(4,4′-dipentoxy-2,2′-bithlophene), polythiophene, poly(3-methylthiophene), and poly(p-phenylenevinylene).
18. The modular chemiresistive sensor system of claim 1 wherein said chemiresistive sensor system is sensitive to concentrations of monomethyl hydrazine and/or NO 2 but insensitive to oxygen, carbon dioxide, methane, acetone, methanol, and water.
19. The modular chemiresistive sensor system of claim 1 where the polymer nanowire comprises an alkyl amine-modified polymer nanowire synthesized from amine-modified aniline monomer, said amine modified nanowire providing a modular chemiresistive sensor system suitable for sensing quantities of CO 2 .
20. The modular chemiresistive sensor system of claim 1 wherein the circuit board comprises a 3 volt reference source and a balanced bridge comprising two resistors of a resistance equal to that of the nanowires.
21. The modular chemiresistive sensor system of claim 18 wherein the polymer nanowire or carbon nanotubes are modified by amide coupling to covalently bind Aβ monomers or oligomers, said modular chemiresistive sensor system suitable for quantitatively detecting Alzheimer-associated biomarkers.