Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use
View Patent ↗The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.
1. A compound, which is 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is crystalline.
3. The compound of claim 2 , which has a melting point of about 182.5° C.
4. The crystalline compound of claim 2 , which has an X-ray powder diffraction pattern with peaks at about 12.7, 14.8, 18.7, 19.0, 19.7 and/or 25.1 degrees 2θ.
5. A method of inhibiting adaptor associated kinase 1 (AAK1) activity, comprising contacting AAK1 with a compound of claim 1 .
6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient or diluent.
7. A method of treating or managing a disease or disorder mediated by AAK1 activity, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 , or a pharmaceutical composition of claim 6 .
8. The method of claim 7 , wherein the disease or disorder is Alzheimer's disease, bipolar disorder, pain, Parkinson's disease, or schizophrenia.
9. The method of claim 8 , wherein the pain is neuropathic pain.
10. The method of claim 9 , wherein the neuropathic pain is fibromyalgia or peripheral neuropathy.