Treatment of intrahepatic cholestatic diseases
View Patent ↗Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
1. A method of treating primary biliary cholangitis by administering to a subject in need thereof a therapeutically effective amount of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)-thio)-2-methylphenoxy)acetic acid or a salt thereof.
2. The method of claim 1 where the (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)-phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof is (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid L-lysine dihydrate salt.
3. The method of claim 1 where the (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)-phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof is administered orally.
4. The method of claim 1 where the daily dose of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof, when calculated as the free acid, is 20-200 mg.
5. The method of claim 3 where the daily dose of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof, when calculated as the free acid, is 50-100 mg.
6. The method of claim 1 where the (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)-phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof is administered once/day.