Bioactive flowable wash-out resistant bone graft material and method for production thereof

1. A flowable bone graft material comprising:

a porous inorganic composition comprising calcium phosphate having a particle size of about 100 μm to about 1,000 μm;

bioactive glass;

one or more biocompatible polymers comprising carboxymethyl cellulose and gelatin; and

a fluid, wherein said fluid is selected from the group consisting of saline, bone marrow aspirate, blood and a mixture thereof

wherein degree of substitution of said carboxymethyl cellulose is from about 0.6 to about 0.8,

wherein said one or more biocompatible polymers does not contain collagen,

wherein molecular weight of said carboxymethyl cellulose is from about 100,000 MW to about 300,000 MW, and

wherein said carboxymethyl cellulose is present in an amount of about 5% to about 15% by weight of said bone graft material.

2. The bone graft material of claim 1 , wherein said carboxymethyl cellulose is sodium carboxymethyl cellulose.

3. The bone graft material of claim 1 , wherein viscosity of said carboxymethyl cellulose is from about 400 MPa-s to about 800 MPa-s.

4. The bone graft material of claim 1 , wherein said gelatin is present in an amount of about 10% to about 20% by weight of said bone graft material excluding the fluid.

5. The bone graft material of claim 1 , wherein said one or more biocompatible polymers are present in an amount of about 15% to about 40% by weight of said bone graft material excluding the fluid.

6. The bone graft material of claim 1 , wherein said calcium phosphate is present in an amount from about 50% to about 70% by weight of said bone graft material excluding the fluid.

7. The bone graft material of claim 1 , wherein said bioactive glass is present in an amount of about 10% to about 20% by weight of said bone graft material excluding the fluid.

8. The bone graft material of claim 1 , wherein said inorganic composition comprises beta-tricalcium phosphate.

9. The bone graft material of claim 1 , wherein the bioactive glass is 45S5 or combeite glass-ceramic.

10. The bone graft material of claim 1 , further comprises an antibiotic, a bone morphogenic protein, or a therapeutic agent.

11. The bone graft material of claim 1 , wherein said bone graft material is capable of being delivered via injection through a 12-gauge cannula or catheter.

12. The bone graft material of claim 1 , wherein the amount of force required to extrude 5 cc of the bone graft material through a 12-guage cannula of 7.5 cm in length at a rate of 0.25 cc/sec is less than 100 N.