SUBSTITUTED TETRACYCLINE COMPOUNDS

1 - 392 . (canceled)

393 . A substituted tetracycline compound of Formula (VIII):

wherein:

T is CR 7td ;

R 4 is alkylamino;

R 4′ is hydrogen;

R te is hydrogen;

R 7ta , R 7tb , and R 7tc are each independently hydrogen, halogen, hydroxyalkyl, hydroxyalkylaminocarbonyl, alkylaminoalkyloxy, aminocarbonyl, alkylaminoalkylaminocarbonyl, aminoalkylaminocarbon yl, methylpiperazinylcarbonyl, alkylaminocarbonyl, heteroarylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl, acylaminoalkylaminocarbonyl, alkoxyaminocarbonyl, alkoxyalkylaminocarbonyl or alkylaminoalkylcarbonylamino, or R 7tb and R 7tc are linked to form a ring; and

R 7td is hydroxyalkyl, alkylaminoalkylaminocarbonyl, dialkylaminoalkylaminocarbonyl, hydroxyalkylaminocarbonyl, aminoalkylaminocarbonyl, methylpiperazinylcarbonyl, heteroarylalkylaminocarbonyl, acylaminoalkylaminocarbonyl, or alkoxyalkylaminocarbonyl, or

a pharmaceutically acceptable salt thereof;

with the proviso that the compound of Formula (VIII) is not

or an enantiomer or diastereomer thereof.

394 . The compound of claim 393 , wherein R 7ta and R 7tc are each hydrogen.

395 . The compound of claim 393 , wherein one of R 7ta , R 7tb , and R 7tc is halogen.

396 . The compound of claim 395 , wherein R 7ta is halogen.

397 . The compound of claim 393 , wherein R 7tb and R 7tc are linked to form a ring.

398 . The compound of claim 393 , wherein R 7td is methylaminoalkylaminocarbonyl, dimethylaminoalkylaminocarbonyl, diethylaminoalkylaminocarbonyl, diisoproprylaminoalkylaminocarbonyl, pyrrolidinylalkylaminocarbonyl, piperidinylalkylaminocarbonyl, furanylalkylaminocarbonyl, ethoxycarbonylalkylaminocarbonyl, methoxyaminocarbonyl, or methoxyalkylaminocarbonyl.

399 . The compound of claim 393 , wherein the compound is represented by any one of the following structural formulas:

or a pharmaceutically acceptable salt thereof.