Nucleoside phosphonate salts
View Patent ↗The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M + is Na + , Li + , K + , Ca 2+ , Mg 2+ , or NR c R d R e R f + and R c , R d , R e and R f are each independently hydrogen or C 1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
1. A method of treating hepatitis B (HBV) or HIV in a subject, comprising administering to said subject a stable crystalline form of a compound having the structure:
or a stereoisomer, diastereomer, enantiomer or racemate thereof, wherein M + is Na + , Li + , K + , Ca 2+ , Mg 2+ , or NR c R d R e R f + , wherein R c , R d , R e and R f are each independently hydrogen or C 1-5 alkyl, and wherein the crystalline form of the compound is greater than 95% pure and retains greater than 95% purity after being kept at about 40° C. for four weeks.
2. The method of claim 1 , wherein said method is a method of treating HIV.
3. The method of claim 1 , wherein the subject is immunocompromised and/or immunosuppressed.
4. The method of claim 1 , wherein said method is a method of treating hepatitis B (HBV).
5. The method of claim 4 , wherein the subject is also infected with HIV.
6. The method of claim 1 , wherein the subject has not been previously administered an antiviral active agent.
7. The method of claim 1 , wherein the subject has developed a resistance or a toxic response to at least one other antiviral compound in response to prior administration of said at least one other antiviral compound.
8. The method of claim 1 , wherein the compound is administered in an amount effective to treat hepatitis B (HBV) or HIV and inhibit the development of resistance to other antiviral compounds.
9. The method of claim 1 , wherein M + is Na + , Li + , K + , or NH 4 + .
10. The method of claim 1 , wherein M + is K + .
11. The method of claim 1 , wherein the compound is present in a pharmaceutical composition.
12. The method of claim 11 , wherein M + is Na + , Li + , K + or NH 4 + .
13. The method of claim 11 , wherein M + is K + .
14. The method of claim 2 , wherein the subject is also infected with hepatitis B virus (HBV).
15. The method of claim 11 , wherein said method is a method of treating HIV.
16. The method of claim 11 wherein said method is a method of treating hepatitis B (HBV).
17. The method of claim 15 , wherein the subject is also infected with hepatitis B (HBV).
18. The method of claim 16 , wherein the subject is also infected with HIV.