Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof

1. A photovitrification method, comprising:

heating, by a light source, a first volume of naturally occurring, non-vitrified corneal stromal material so as to result in a non-naturally occurring, photovitrified corneal stromal material;

wherein the light source is a laser source or an intense pulsed light source;

wherein the heating is:

i) at a heating rate between 100 degrees per second and 20,000 degrees per second, and

ii) for a minimum time period required to produce a maximum temperature between 50° C. and 100° C.; and

wherein the non-naturally occurring, photovitrified corneal stromal material has the following structure and properties:

i) a biocompatible glass-like structure,

ii) an elastic modulus value of 0.33 to 33 MPa,

iii) a density value of 1.1 to 3.2 g/cm 3 , and

iv) a persistent vitrified condition at a physiological temperature wherein the persistence is for a duration of at least one month and the physiological temperature is in the range of 30° C. to 40° C.

2. The photovitrification method of claim 1 , wherein the non-naturally occurring, photovitrified corneal stromal material is configured to be located in a second volume of non-vitrified, naturally occurring, corneal stromal tissue.

3. The photovitrification method of claim 1 , wherein the photovitrification method is used for at least one of the following applications:

i) vision;

ii) vision improvement;

iii) a compensation for at least one symptom of: at least one ophthalmic disorder, at least one ophthalmic disease; at least one ophthalmic condition; at least one ophthalmic injury, and any combination thereof;

iv) a treatment of at least one of: at least one ophthalmic disorder, at least one ophthalmic disease; at least one ophthalmic condition; at least one ophthalmic injury, and any combination thereof;

v) a stabilization of the treatment; and

vi) any combination thereof.

4. The photovitrification method of claim 1 , wherein the photovitrification method is used for at least one of vision or improving vision by modifying at least one corneal optical aberration, wherein the at least one corneal optical aberration comprises at least one of:

i) at least one lower order aberration, wherein the at least one lower order aberration is at least one of: tip, tilt, defocus, and astigmatism;

ii) at least one higher order aberration, wherein the at least one higher order aberration is at least one of: spherical aberration, coma, trefoil, and secondary astigmatism; and

iii) at least one aberration that is not predominantly described by Zernike polynomials and Zernike polynomial coefficients up to and including 8th radial order.

5. The photovitrification method of claim 4 , wherein the photovitrification method is configured to result in the improving vision by measurably compensating for age-related focus dysfunction;

wherein the measurably compensating for the age-related focus dysfunction is configured to result in at least one of the following:

i) a functional simultaneous vision at multiple distances comprising a near distance, an intermediate distance, and a far distance and

ii) an increased depth of field;

wherein the functional simultaneous vision is 20/40 or better in Snellen terms, equivalent to 0.3 log MAR or less;

wherein the near distance is 40 cm, the intermediate distance is 60 to 100 cm, and the far distance is at least 300 cm; and

wherein the increased depth of field includes a range of distances between 40 to 1000 cm for which the vision is functional.

6. The photovitrification method of claim 4 , wherein the photovitrification method is configured to slow, at a measurable rate, at least one of:

i) a progression of myopia,

ii) a progression of axial elongation, and

iii) any combination thereof;

wherein the measurable rate is reduced by at least 20% relative to a control group; and

wherein the control group uses conventional eyeglasses or contact lenses as the only visual correction aid.

7. The photovitrification method of claim 4 , wherein the photovitrification method is configured to result in at least one of:

i) image magnification on a retina,

ii) image relocation on the retina, and

iii) any combination thereof;

wherein the image magnification provides a retinal image that overlaps functional regions of the retina; and

wherein the image relocation on the retina is to position the retinal image to at least one preferred retinal location that overlaps functional regions of the retina.

8. The photovitrification method of claim 1 , wherein the photovitrification method is configured to result in stabilizing or decreasing or any combination thereof of at least one of:

i) naturally occurring corneal ectasia,

ii) iatrogenic corneal ectasia, and

iii) any combination thereof;

wherein the decrease in corneal ectasia includes at least one local change to corneal curvature within at least one local area bounded by r,θ coordinates; and

wherein the change to corneal curvature is between 0.10 diopters (D) and 20 D.

9. The photovitrification method of claim 1 , wherein the photovitrification method is configured to result in stabilizing or increasing or any combination thereof of at least one of:

i) adhesion of apposed stromal tissue, and

ii) adhesion of donor transplanted corneal stromal tissue or synthetic implanted material to apposed host donor stromal tissue; and

wherein an adhesion value of the photovitrified material to other corneal stromal material is 0.08 to 0.8 MPa.

10. The photovitrification method of claim 1 , further comprising:

applying, by a pressure-inducing device, an external stress to the first volume of naturally occurring, non-vitrified corneal stromal material, the modified, non-naturally occurring, photovitrified corneal stromal material, or both, so as to result in an enhancement of at least 5% in density of the non-naturally occurring, photovitrified corneal stromal material.