Devices for targeted delivery of therapeutic implants
A barrel adapter for a syringe having a barrel and plunger. The adapter comprises a barrel tip and a needle retraction mechanism having a needle subassembly with a needle and a lumen, actuator subassembly, and biasing member. The needle subassembly moves from an injection to a retracted position within the barrel tip. The actuator subassembly includes a retainer connected to the barrel tip, a stylet held in a stylet disc, and a prong passing into the retainer. The stylet slides within the needle lumen and is spaced from the needle tip in the injection position. The biasing member biases the NOM from the retainer. A locking arrangement compresses the biasing member when locked and releases the biasing member when actuated by depression of the plunger, which moves the prong against the retainer. The biasing member moves the needle and stylet from the injection position to the retracted position when released.
1. A barrel adapter for a delivery syringe having a barrel and a plunger assembly adapted to move within the barrel, the barrel adapter comprising:
a barrel tip configured to be sealingly engaged with a distal end of the barrel;
a needle retraction mechanism including:
a needle subassembly including a needle and a needle-over-mold through which the needle extends, the needle having a lumen, wherein the needle subassembly is disposed at least partially within the barrel tip and adapted to move from an injection position in which the needle extends from a distal end of the barrel tip to a retracted position,
an actuator subassembly including a needle-over-mold retainer connected to the barrel tip, a stylet, a stylet disc holding a proximal end of the stylet, at least one prong passing through the stylet disc and into the needle-over-mold retainer, the at least one prong being actuable in response to movement of the plunger assembly within the barrel, wherein the stylet is axially slidable and at least partially disposed within the needle lumen and the stylet is proximally disposed and spaced from a distal tip of the needle when the needle is in the injection position, and
at least one biasing member disposed between the needle-over-mold and the needle-over-mold retainer so as to bias the needle-over-mold away from the needle-over-mold retainer; and
an actuable locking arrangement disposed to maintain the at least one biasing member in an energized position when the locking arrangement is locked and release the at least one biasing member when actuated by the actuator subassembly, the locking arrangement being actuable by depression of the plunger assembly to move the at least one prong against the needle-over-mold retainer, the at least one biasing member being disposed to provide relative motion of the needle and stylet from the injection position to the retracted position when the biasing member is released from the energized position.
2. The barrel adapter of claim 1 , wherein the locking arrangement includes a releasable coupling between the needle-over-mold and the needle-over-mold retainer.
3. The barrel adapter of claim 2 , wherein the releasable coupling is formed between at least one retainer arm of the needle-over-mold retainer and a needle-over- mold shelf of the needle-over-mold.
4. The barrel adapter of claim 3 , wherein an actuating end of the at least one prong is configured to move the at least one retainer arm out of engagement with the needle- over-mold shelf so as to actuate the locking arrangement in response to depression of the plunger assembly.
5. The barrel adapter of claim 4 , wherein the at least one prong comprises two prongs and the at least one retainer arm comprises two retainer arms.
6. The barrel adapter of claim 1 , wherein a proximal end of the at least one prong is disposed in the plunger assembly.
7. The barrel adapter of claim 1 , wherein the stylet disc is disposed adjacent the plunger assembly such that depression of the plunger assembly results in an initial axial movement of the stylet within the needle lumen before the depression of the plunger assembly causes the actuation of the locking arrangement.
8. The barrel adapter of claim 7 , wherein the needle lumen is configured to receive an implant and a plug disposed distally to the implant, and wherein the stylet disc is disposed such that the initial axial movement of the stylet forces the plug out of the needle without forcing the implant out of the needle.
9. The barrel adapter of claim 1 , wherein the needle subassembly further comprises a needle hub disposed adjacent the needle-over-mold, and wherein the needle hub is configured to engage the stylet disc upon retraction of the needle.
10. The barrel adapter of claim 1 , wherein the needle is disposed within at least one of the barrel tip and the barrel when the needle is in the retracted position.
11. An automatically retractable implant delivery syringe comprising:
a barrel having a distal end and a proximal end;
a plunger assembly configured to move within the barrel;
a barrel tip sealingly engaged with the distal end of the barrel;
a needle retraction mechanism including:
a needle subassembly including a needle and a needle-over-mold through which
the needle extends, the needle having a lumen, wherein the needle subassembly is disposed at least partially within the barrel tip and adapted to move from an injection position in which the needle extends from a distal end of the barrel tip to a retracted position in which the needle is disposed within at least one of the barrel tip or the barrel,
an actuator subassembly including a needle-over-mold retainer connected to the barrel tip, a stylet, a stylet disc holding a proximal end of the stylet, at least one prong passing through the stylet disc and into the needle-over-mold retainer, the at least one prong being actuable in response to movement of the plunger assembly within the barrel, wherein the stylet is axially slidable and at least partially disposed within the needle lumen and the stylet is proximally disposed and spaced from a distal tip of the needle when the needle is in the injection position, and
at least one biasing member disposed between the needle-over-mold and the needle-over-mold retainer so as to bias the needle-over-mold away from the needle-over-mold retainer; and
an actuable locking arrangement disposed to maintain the at least one biasing member in an energized position when the locking arrangement is locked and release the at least one biasing member when actuated by the actuator subassembly, the locking arrangement being actuable by depression of the plunger assembly to move the at least one prong against the needle-over-mold retainer, the at least one biasing member being disposed to provide relative motion of the needle and stylet from the injection position to the retracted position when the biasing member is released from the energized position.
12. The delivery syringe of claim 11 , wherein the locking arrangement includes a releasable coupling between the needle-over-mold and the needle-over-mold retainer.
13. The delivery syringe of claim 12 , wherein the releasable coupling is formed between at least one retainer arm of the needle-over-mold retainer and a needle-over- mold shelf of the needle-over-mold.
14. The delivery syringe of claim 13 , wherein an actuating end of the at least one prong is configured to move the at least one retainer arm out of engagement with the needle-over-mold shelf so as to actuate the locking arrangement in response to depression of the plunger assembly.
15. The delivery syringe of claim 11 , wherein a proximal end of the at least one prong is disposed in the plunger assembly.
16. The delivery syringe of claim 11 , wherein the stylet disc is disposed adjacent the plunger assembly such that depression of the plunger assembly results in an initial axial movement of the stylet within the needle lumen before the depression of the plunger assembly causes the actuation of the locking arrangement.
17. The delivery syringe of claim 11 , wherein the needle lumen is configured to receive an implant and a plug disposed distally to the implant, and wherein the stylet disc is disposed such that the initial axial movement of the stylet forces the plug out of the needle without forcing the implant out of the needle.
18. The delivery syringe of claim 11 , wherein the needle subassembly further comprises a needle hub disposed adjacent the needle-over-mold, and wherein the needle hub is configured to engage the stylet disc upon retraction of the needle.